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Ligand · KFZ

KFZ · 2-{[(2,5-dichlorophenyl)methyl]sulfanyl}-5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

KFZ, 2-{[(2,5-dichlorophenyl)methyl]sulfanyl}-5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (C14 H12 Cl2 N4 O S, 355.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
KFZ
Formula
C14 H12 Cl2 N4 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

KFZ in 2 structures; the first of them:

  • 3ZWT · Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor · KFZ A1401 · binds MET43, LEU46, GLN47, PRO52, ALA55, HIS56, ALA59, PHE62 and 10 more
  • 3ZWT · Structure of human dihydroorotate dehydrogenase with a bound inhibitor · KFZ A1401 · binds MET43, LEU46, GLN47, PRO52, ALA55, HIS56, ALA59, PHE62 and 10 more

Residues it binds most

ALA 2, LEU 2, PHE 2, PRO 2, THR 2, TYR 2, VAL 2, ARG 2, GLN 2, HIS 2 (residue and the binding sites it lines).

Found with

  • FMN · Flavin mononucleotide
  • ORO · Orotic acid
  • CL · Chloride ion
  • SO4 · Sulfate ion
  • ACT · Acetate ion

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