UniProt P24941
Cyclin-dependent kinase 2 (P24941)
Cyclin-dependent kinase 2 (UniProt P24941), EC 2.7.11.22: 853 experimental structures and 1 predicted model on GenesisL1, 77 ligands bound, 173 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P24941
- Protein
- Cyclin-dependent kinase 2
- EC
- 2.7.11.22
- Experimental structures
- 853
- Predicted models
- 1
- Ligands
- 77
- Pockets
- 173 · 49 records with a druggable one
Structures
854 records of P24941 in the MolNFT archive: 853 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AQ1 | Human cyclin dependent kinase 2 complexed with the inhibitor staurosporine | x-ray diffraction | A | — | — |
| 1AQ1 | Human cyclin dependent kinase 2 complexed with the inhibitor staurosporine | x-ray diffraction | A | — | — |
| 1B38 | Human cyclin-dependent kinase 2 | x-ray diffraction | A | — | — |
| 1B38 | Human cyclin-dependent kinase 2 | x-ray diffraction | A | — | — |
| 1B39 | Human cyclin-dependent kinase 2 phosphorylated on thr 160 | x-ray diffraction | A | — | — |
| 1B39 | Human cyclin-dependent kinase 2 phosphorylated on thr 160 | x-ray diffraction | A | — | — |
| 1BUH | Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein CKSHS1 | x-ray diffraction | A | — | — |
| 1BUH | Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein CKSHS1 | x-ray diffraction | A | — | — |
| 1CKP | Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol B | x-ray diffraction | A | — | — |
| 1CKP | Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol B | x-ray diffraction | A | — | — |
| 1DI8 | The structure of cyclin-dependent kinase 2 (CDK2) in complex with… | x-ray diffraction | A | — | — |
| 1DI8 | The structure of cyclin-dependent kinase 2 (CDK2) in complex with… | x-ray diffraction | A | — | — |
| 1DM2 | Human cyclin-dependent kinase 2 complexed with the inhibitor hymenialdisine | x-ray diffraction | A | — | — |
| 1DM2 | Human cyclin-dependent kinase 2 complexed with the inhibitor hymenialdisine | x-ray diffraction | A | — | — |
| 1E1V | Human cyclin dependent kinase 2 complexed with the inhibitor NU2058 | x-ray diffraction | A | — | — |
| 1E1V | Human cyclin dependent kinase 2 complexed with the inhibitor NU2058 | x-ray diffraction | A | — | — |
| 1E1X | Human cyclin dependent kinase 2 complexed with the inhibitor NU6027 | x-ray diffraction | A | — | — |
| 1E1X | Human cyclin dependent kinase 2 complexed with the inhibitor NU6027 | x-ray diffraction | A | — | — |
| 1E9H | Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate… | x-ray diffraction | A, C | — | — |
| 1E9H | Thr 160 phosphorylated CDK2 - human cyclin A3 complex with the inhibitor indirubin-5-sulphonate… | x-ray diffraction | A, C | — | — |
| 1F5Q | Crystal structure of murine gamma herpesvirus cyclin complexed to human cyclin dependent kinase 2 | x-ray diffraction | A, C | — | — |
| 1F5Q | Crystal structure of murine gamma herpesvirus cyclin complexed to human cyclin dependent kinase 2 | x-ray diffraction | A, C | — | — |
| 1FIN | Cyclin a-cyclin-dependent kinase 2 complex | x-ray diffraction | A, C | — | — |
| 1FIN | Cyclin a-cyclin-dependent kinase 2 complex | x-ray diffraction | A, C | — | — |
| 1FQ1 | Crystal structure of kinase associated phosphatase (kap) in complex with phospho-CDK2 | x-ray diffraction | B | — | — |
| 1FQ1 | Crystal structure of kinase associated phosphatase (kap) in complex with phospho-CDK2 | x-ray diffraction | B | — | — |
| 1FVT | The structure of cyclin-dependent kinase 2 (CDK2) in complex with an oxindole inhibitor | x-ray diffraction | A | — | — |
| 1FVT | The structure of cyclin-dependent kinase 2 (CDK2) in complex with an oxindole inhibitor | x-ray diffraction | A | — | — |
| 1FVV | The structure of CDK2/CYCLIN a in complex with an oxindole inhibitor | x-ray diffraction | A, C | — | — |
| 1FVV | The structure of CDK2/CYCLIN a in complex with an oxindole inhibitor | x-ray diffraction | A, C | — | — |
| 1G5S | Crystal structure of human cyclin dependent kinase 2 (CDK2) in complex with the inhibitor H717 | x-ray diffraction | A | — | — |
| 1G5S | Crystal structure of human cyclin dependent kinase 2 (CDK2) in complex with the inhibitor H717 | x-ray diffraction | A | — | — |
| 1GIH | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GIH | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GII | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GII | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GIJ | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GIJ | Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1GY3 | pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate | x-ray diffraction | A, C | — | — |
| 1GY3 | PCDK2/CYCLIN a in complex with mgadp, nitrate and peptide substrate | x-ray diffraction | A, C | — | — |
| 1GZ8 | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR… | x-ray diffraction | A | — | — |
| 1GZ8 | Human cyclin dependent kinase 2 complexed with the inhibitor 2-amino… | x-ray diffraction | A | — | — |
| 1H00 | CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H00 | CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H01 | CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H01 | CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H07 | CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H07 | CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H08 | CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H08 | CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor | x-ray diffraction | A | — | — |
| 1H0V | Human cyclin dependent protein kinase 2 in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 1H0V | Human cyclin dependent protein kinase 2 in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 1H0W | Human cyclin dependent protein kinase 2 in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 1H0W | Human cyclin dependent protein kinase 2 in complex with the inhibitor… | x-ray diffraction | A | — | — |
| 1H1P | Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058 | x-ray diffraction | A, C | — | — |
| 1H1P | Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU2058 | x-ray diffraction | A, C | — | — |
| 1H1Q | Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094 | x-ray diffraction | A, C | — | — |
| 1H1Q | Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU6094 | x-ray diffraction | A, C | — | — |
| 1H1R | Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086 | x-ray diffraction | A, C | — | — |
| 1H1R | Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU6086 | x-ray diffraction | A, C | — | — |
794 records more on the page itself.
Ligands
- FB8 · 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine · in 4 records
- SO4 · Sulfate ion · in 3 records
- 1QK · 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium · in 2 records
- 23D · N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine · in 2 records
- 26D · Pyridine-2,6-diamine · in 2 records
- 65L · [1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol · in 2 records
- 6QB · 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl) amino]pyrimidin-4-yl]pyridin-2-one · in 2 records
- 7TH · 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid · in 2 records
- 80E · 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(methoxycarbonyl) benzoic acid · in 2 records
- 8QT · (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol · in 2 records
- 9YZ · methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate · in 2 records
- 9Z2 · ~{N}-(4-pyrimidin-2-ylphenyl)propanamide · in 2 records
- 9ZB · 1-(4-ethyl-2,3-dihydroquinoxalin-1-yl)propan-1-one · in 2 records
- AAK · ~{tert}-butyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate · in 2 records
- AEQ · methyl 1-propanoyl-3,4-dihydro-2~{H}-quinoline-6-carboxylate · in 2 records
- AQG · 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide · in 2 records
- BR · Bromide ion · in 2 records
- CL · Chloride ion · in 2 records
- FC8 · ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine · in 2 records
- FCQ · 5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine · in 2 records
- HGH · 2-[3-[(2-azanyl-9~{H}-purin-6-yl)oxy]phenyl]ethanoic acid · in 2 records
- HGK · 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl) oxy]phenyl]ethanoic acid · in 2 records
- HGQ · 4-bromanyl-1~{H}-pyridin-2-one · in 2 records
- HGW · 5-iodanylpyrimidine · in 2 records
- HH8 · 4-bromanyl-1,8-naphthyridine · in 2 records
- HHN · 5-bromanylpyrimidine · in 2 records
- HHQ · 4-iodanyl-3~{H}-pyridin-2-one · in 2 records
- HHT · 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid · in 2 records
- HHW · (~{E})-3-[3-[(4-chlorophenyl)carbamoyl]phenyl]prop-2-enoic acid · in 2 records
- I74 · (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol · in 2 records
Experiment against prediction
- 1PYE chain A against the predicted model P24941: TM-score 0.97, RMSD 1.05 Å
- 1PYE chain A against the predicted model P24941: TM-score 0.97, RMSD 1.05 Å
- 1AQ1 chain A against the predicted model P24941: TM-score 0.97, RMSD 1.14 Å
- 1AQ1 chain A against the predicted model P24941: TM-score 0.97, RMSD 1.14 Å
- 2BHH chain A against the predicted model P24941: TM-score 0.97, RMSD 1.10 Å
- 2BHH chain A against the predicted model P24941: TM-score 0.97, RMSD 1.10 Å
- 2VTQ chain A against the predicted model P24941: TM-score 0.97, RMSD 1.14 Å
- 2VTQ chain A against the predicted model P24941: TM-score 0.97, RMSD 1.14 Å
- 5D1J chain A against the predicted model P24941: TM-score 0.97, RMSD 1.15 Å
- 5D1J chain A against the predicted model P24941: TM-score 0.97, RMSD 1.15 Å
Elsewhere
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