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Ligand · CK4

CK4 · 4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine

CK4, 4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine (C16 H13 F3 N4 S, 350.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within…

Component
CK4
Formula
C16 H13 F3 N4 S
Class
ligand
Structures
3
PDB entries
2

Binding sites

CK4 in 3 structures; the first of them:

  • 1PXL · HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR… · CK4 A500 · binds ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82, LEU83 and 9 more
  • 1PXL · Human cyclin dependent kinase 2 complexed with the inhibitor… · CK4 A500 · binds ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82, LEU83 and 9 more
  • 2C5V · Differential binding of inhibitors to active and inactive CDK2 provides insights for drug… · CK4 A1297 · binds ILE10, GLU12, VAL18, ALA31, LYS33, GLU51, VAL64, PHE80 and 9 more

Residues it binds most

ASP 4, LEU 4, PHE 4, VAL 4, GLU 4, ALA 4, GLN 4, LYS 4, HIS 4, ILE 4 (residue and the binding sites it lines).

Found with

  • NH2 · Amino group

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