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Ligand · FCP

FCP · (2R)-1-[4-({6-[(2,6-difluorophenyl)amino]pyrimidin-4-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol

FCP, (2R)-1-[4-({6-[(2,6-difluorophenyl)amino]pyrimidin-4-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol (C21 H23 F2 N5 O2, 415.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
FCP
Formula
C21 H23 F2 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

FCP in 2 structures; the first of them:

  • 1H00 · CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor · FCP A1400 · binds ILE10, GLU12, VAL18, ALA31, LYS33, VAL64, PHE80, GLU81 and 9 more
  • 1H00 · CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor · FCP A1400 · binds ILE10, GLU12, VAL18, ALA31, LYS33, VAL64, PHE80, GLU81 and 9 more

Residues it binds most

ALA 2, ASP 2, GLU 2, LEU 2, LYS 2, PHE 2, VAL 2, GLN 2, HIS 2, ILE 2 (residue and the binding sites it lines).

Found with

  • FAP · (2S)-1-[4-({6-[(2,6-difluorophenyl)amino]pyrimidin-4-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol
  • ACE · Acetyl group

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