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Ligand · CK8

CK8 · N-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine

CK8, N-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine (C17 H19 N5 S, 325.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within…

Component
CK8
Formula
C17 H19 N5 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

CK8 in 4 structures; the first of them:

  • 1PXP · HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR… · CK8 A500 · binds ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82, LEU83 and 8 more
  • 2C5N · Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug… · CK8 A1297 · binds ILE10, TYR15, VAL18, ALA31, LYS33, VAL64, PHE80, GLU81 and 8 more
  • 1PXP · Human cyclin dependent kinase 2 complexed with the inhibitor… · CK8 A500 · binds ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82, LEU83 and 8 more
  • 2C5N · Differential binding of inhibitors to active and inactive CDK2 provides insights for drug… · CK8 A1297 · binds ILE10, TYR15, VAL18, ALA31, LYS33, VAL64, PHE80, GLU81 and 8 more

Residues it binds most

ASP 6, LEU 6, PHE 6, VAL 6, LYS 6, ALA 6, GLN 6, GLU 6, HIS 6, ILE 6 (residue and the binding sites it lines).

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