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Ligand · 2PU

2PU · 1-(5-oxo-2,3,5,9B-tetrahydro-1H-pyrrolo[2,1-a]isoindol-9-yl)-3-(5-pyrrolidin-2-yl-1H-pyrazol-3-yl)-urea

2PU, 1-(5-oxo-2,3,5,9B-tetrahydro-1H-pyrrolo[2,1-a]isoindol-9-yl)-3-(5-pyrrolidin-2-yl-1H-pyrazol-3-yl)-urea (C19 H22 N6 O2, 366.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
2PU
Formula
C19 H22 N6 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

2PU in 2 structures; the first of them:

  • 1GIJ · Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor · 2PU A501 · binds ILE10, GLY11, GLU12, GLY13, VAL18, ALA31, LYS33, VAL64 and 12 more
  • 1GIJ · Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor · 2PU A501 · binds ILE10, GLY11, GLU12, GLY13, VAL18, ALA31, LYS33, VAL64 and 12 more

Residues it binds most

VAL 2, ALA 2, ASP 2, GLN 2, GLU 2, GLY 2, HIS 2, ILE 2, LEU 2, LYS 2 (residue and the binding sites it lines).

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