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Ligand · LS5

LS5 · 3-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indole

LS5, 3-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indole (C16 H15 N5 O3 S, 357.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
LS5
Formula
C16 H15 N5 O3 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

LS5 in 4 structures; the first of them:

  • 1KE9 · Cyclin-dependent kinase 2 (CDK2) complexed with… · LS5 A299 · binds GLU8, ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82 and 7 more
  • 4FKP · Crystal structure of the cdk2 in complex with oxindole inhibitor · LS5 A301 · binds GLU8, ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82 and 8 more
  • 1KE9 · Cyclin-dependent kinase 2 (CDK2) complexed with 3-{[4-({[AMINO(IMINO)… · LS5 A299 · binds GLU8, ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82 and 7 more
  • 4FKP · Crystal structure of the CDK2 in complex with oxindole inhibitor · LS5 A301 · binds GLU8, ILE10, VAL18, ALA31, VAL64, PHE80, GLU81, PHE82 and 8 more

Residues it binds most

ALA 4, GLU 4, LEU 4, PHE 4, VAL 4, ASP 4, GLN 4, HIS 4, ILE 4, LYS 4 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • ACE · Acetyl group

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