MolNFT v1 · #12351 · protein
Cyclin-dependent kinase 2 (CDK2) complexed with 3-{[4-({[AMINO(IMINO) METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-oxo-2,3-dihydro-1H-indole
1KE9 · Cell division protein kinase 2: “Cyclin-dependent kinase 2 (CDK2) complexed with 3-{[4-({[AMINO(IMINO)…”. X-ray diffraction, 1 ligand (LS5), 1 pocket (best druggability 0.68). MolNFT v1 #12351 on GenesisL1: 3D structure, binding…
- PDB
- 1KE9
- Type
- protein
- Length
- 281 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein kinase 2
- EC
- 2.7.1.37
- UniProt
- P24941
- Ligands
- LS5
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein kinase 2 (EC 2.7.1.37) | protein | 281 | 36% helix, 17% strand | P24941 |
Ligands and binding sites
- LS5 · 3-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indole · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 232 | 0.68 | 0.85 | 26 | LS5 |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Elsewhere: RCSB PDB 1KE9 · PDBe 1KE9 · UniProt P24941
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.