UniProt P11172
Uridine 5'-monophosphate synthase (P11172)
Uridine 5'-monophosphate synthase (UniProt P11172), EC 2.4.2.10, 4.1.1.23: 124 experimental structures and 1 predicted model on GenesisL1, 29 ligands bound, 353 pockets. Binding sites, druggability and experiment against…
- UniProt
- P11172
- Protein
- Uridine 5'-monophosphate synthase
- EC
- 2.4.2.10, 4.1.1.23
- Experimental structures
- 124
- Predicted models
- 1
- Ligands
- 29
- Pockets
- 353 · 119 records with a druggable one
Structures
125 records of P11172 in the MolNFT archive: 124 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EAW | Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase) | x-ray diffraction | A, B | SO4 | 2 (best 0.69) |
| 2EAW | Human ump synthase (C-terminal domain- orotidine 5'- monophosphate decarboxylase) | x-ray diffraction | A, B | SO4 | 2 (best 0.69) |
| 2JGY | The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate… | x-ray diffraction | A, B | — | 3 (best 0.65) |
| 2JGY | The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate… | x-ray diffraction | A, B | — | 3 (best 0.65) |
| 2P1F | Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase) | x-ray diffraction | A | SO4, NA | 2 (best 0.56) |
| 2P1F | Human ump synthase (C-terminal domain-orotidine 5'-monophosphate decarboxylase) | x-ray diffraction | A | SO4, NA | 2 (best 0.56) |
| 2QCC | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase, apo… | x-ray diffraction | A, B | SO4 | 3 (best 0.71) |
| 2QCC | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase, apo… | x-ray diffraction | A, B | SO4 | 3 (best 0.71) |
| 2QCD | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase… | x-ray diffraction | A, B | U5P | 2 (best 0.76) |
| 2QCD | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase… | x-ray diffraction | A, B | U5P | 2 (best 0.76) |
| 2QCE | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase… | x-ray diffraction | A | SO4, CL | 1 (best 0.57) |
| 2QCE | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase… | x-ray diffraction | A | SO4, CL | 1 (best 0.57) |
| 2QCF | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of… | x-ray diffraction | A | 5FU | 1 (best 0.51) |
| 2QCF | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (ASP312ASN mutant) of… | x-ray diffraction | A | 5FU | 1 (best 0.51) |
| 2QCG | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase… | x-ray diffraction | A, B | 5BU | 4 (best 0.75) |
| 2QCG | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase… | x-ray diffraction | A, B | 5BU | 4 (best 0.75) |
| 2QCH | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase… | x-ray diffraction | A, B | IOD, 5IU, UMP | 4 (best 0.76) |
| 2QCH | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase… | x-ray diffraction | A, B | IOD, 5IU, UMP | 4 (best 0.76) |
| 2QCL | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of… | x-ray diffraction | A, B | OMP | 6 (best 0.79) |
| 2QCL | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (ASP312ASN mutant) of… | x-ray diffraction | A, B | OMP | 6 (best 0.79) |
| 2QCM | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of… | x-ray diffraction | A | JW5 | 1 (best 0.54) |
| 2QCM | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (ASP312ASN mutant) of… | x-ray diffraction | A | JW5 | 1 (best 0.54) |
| 2QCN | Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase with… | x-ray diffraction | A, B | SO4, U5P | 5 (best 0.72) |
| 2QCN | Covalent complex of the orotidine-5'-monophosphate decarboxylase domain of human ump synthase with… | x-ray diffraction | A, B | U5P, SO4 | 5 (best 0.72) |
| 2V30 | Human orotidine 5'-phosphate decarboxylase domain of uridine monophospate synthetase (UMPS) in… | x-ray diffraction | A, B | U5P | 5 (best 0.77) |
| 2V30 | Human orotidine 5'-phosphate decarboxylase domain of uridine monophospate synthetase (umps) in… | x-ray diffraction | A, B | U5P | 5 (best 0.77) |
| 2WNS | Human Orotate phosphoribosyltransferase (OPRTase) domain of Uridine 5' -monophosphate synthase… | x-ray diffraction | A, B | OMP, CL | 4 (best 0.73) |
| 2WNS | Human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-monophosphate synthase… | x-ray diffraction | A, B | OMP, CL | 4 (best 0.73) |
| 3BGG | Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP | x-ray diffraction | A | BMP | 2 (best 0.57) |
| 3BGG | Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with bmp | x-ray diffraction | A | BMP | 2 (best 0.57) |
| 3BGJ | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by… | x-ray diffraction | A, B | U5P | 6 (best 0.73) |
| 3BGJ | Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by… | x-ray diffraction | A, B | U5P | 6 (best 0.73) |
| 3BK0 | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP | x-ray diffraction | A, B | SO4, CNU | 6 (best 0.76) |
| 3BK0 | Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with 5-cn-ump | x-ray diffraction | A, B | CNU, SO4 | 6 (best 0.76) |
| 3BVJ | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with XMP | x-ray diffraction | A, B | SO4, XMP | 5 (best 0.76) |
| 3BVJ | Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with xmp | x-ray diffraction | A, B | XMP, SO4 | 5 (best 0.76) |
| 3DBP | Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP | x-ray diffraction | A, B | SO4, NUP | 3 (best 0.77) |
| 3DBP | Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with 6-NH2-ump | x-ray diffraction | A, B | SO4, NUP | 3 (best 0.77) |
| 3EWU | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP… | x-ray diffraction | A, B | UEP, SO4 | 5 (best 0.76) |
| 3EWU | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-ump… | x-ray diffraction | A, B | UEP, SO4 | 5 (best 0.76) |
| 3EWW | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent… | x-ray diffraction | A, B | U1P | 5 (best 0.76) |
| 3EWW | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-ump, covalent… | x-ray diffraction | A, B | U1P | 5 (best 0.76) |
| 3EWX | K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded… | x-ray diffraction | A | BMP | 1 (best 0.52) |
| 3EWX | K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-ump, degraded… | x-ray diffraction | A | BMP | 1 (best 0.52) |
| 3EWY | K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP | x-ray diffraction | A | U5P | 1 (best 0.56) |
| 3EWY | K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with omp, decarboxylated to ump | x-ray diffraction | A | U5P | 1 (best 0.56) |
| 3EWZ | human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP | x-ray diffraction | A, B, C, D | SO4, CNU | 6 (best 0.86) |
| 3EWZ | Human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano- ump | x-ray diffraction | A, B, C, D | SO4, CNU | 6 (best 0.86) |
| 3EX1 | human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP | x-ray diffraction | A, B | U5P, 6CN | 4 (best 0.75) |
| 3EX1 | Human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-ump, converted to ump | x-ray diffraction | A, B | U5P, 6CN | 4 (best 0.75) |
| 3EX2 | human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP | x-ray diffraction | A, B | 6CN | 2 (best 0.74) |
| 3EX2 | Human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano- ump | x-ray diffraction | A, B | 6CN | 2 (best 0.74) |
| 3EX3 | human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct | x-ray diffraction | A, B | U5P | 4 (best 0.71) |
| 3EX3 | Human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido- ump, covalent adduct | x-ray diffraction | A, B | U5P | 4 (best 0.71) |
| 3EX4 | human orotidyl-5'-monophosphate decarboxylase in complex with BMP | x-ray diffraction | A | BMP | 1 (best 0.52) |
| 3EX4 | Human orotidyl-5'-monophosphate decarboxylase in complex with bmp | x-ray diffraction | A | BMP | 1 (best 0.52) |
| 3EX6 | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent… | x-ray diffraction | A, B | SO4, CL, U5P | 5 (best 0.74) |
| 3EX6 | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-ump, covalent… | x-ray diffraction | A, B | SO4, CL, U5P | 5 (best 0.74) |
| 3G3D | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by… | x-ray diffraction | A, B | 5FU, SO4 | 6 (best 0.71) |
| 3G3D | Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by… | x-ray diffraction | A, B | 5FU, SO4 | 6 (best 0.71) |
65 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 64 records
- OMP · Orotidine-5'-monophosphate · in 28 records
- U · Uridine-5'-monophosphate · in 24 records
- U5P · Uridine-5'-monophosphate · in 22 records
- PRO · Proline · in 16 records
- BMP · 6-hydroxyuridine-5'-phosphate · in 12 records
- 5FU · 5-fluoro-uridine-5'-monophosphate · in 8 records
- CL · Chloride ion · in 8 records
- 16B · N-hydroxycytidine 5'-(dihydrogen phosphate) · in 4 records
- 6CN · 6-cyanouridine 5'-phosphate · in 4 records
- CNU · 5-cyano-uridine-5'-monophosphate · in 4 records
- NA · Sodium ion · in 4 records
- 5BU · 5-bromo-uridine-5'-monophosphate · in 2 records
- 5IU · 5-iodo-2'-deoxyuridine-5'-monophosphate · in 2 records
- 6AU · 6-acetyluridine 5'-phosphate · in 2 records
- IOD · Iodide ion · in 2 records
- JW5 · 6-(hydroxymethyl)uridine 5'-(dihydrogen phosphate) · in 2 records
- NUP · 6-aminouridine 5'-monophosphate · in 2 records
- PFU · (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol · in 2 records
- QRT · [(2~{R},3~{S},4~{R},5~{R})-5-[6-aminocarbonyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl) oxolan-2-yl]methyl dihydrogen phosphate · in 2 records
- QRZ · [(2~{R},3~{S},4~{R},5~{R})-5-[6-carbamothioyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl) oxolan-2-yl]methyl dihydrogen phosphate · in 2 records
- S5P · 6-sulfanyluridine-5'-phosphate · in 2 records
- TKW · 5-hydroxycytidine 5'-(dihydrogen phosphate) · in 2 records
- U1P · 6-[(E)-iminomethyl]uridine 5'-phosphate · in 2 records
- UEP · 6-ethyluridine 5'-phosphate · in 2 records
- UFT · 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate) · in 2 records
- UMP · 2'-deoxyuridine 5'-monophosphate · in 2 records
- UP6 · 6-aza uridine 5'-monophosphate · in 2 records
- XMP · Xanthosine-5'-monophosphate · in 2 records
Experiment against prediction
- 3L0K chain B against the predicted model P11172: TM-score 1.00, RMSD 0.17 Å
- 3G3M chain A against the predicted model P11172: TM-score 1.00, RMSD 0.18 Å
- 3EWX chain A against the predicted model P11172: TM-score 1.00, RMSD 0.18 Å
- 3EWX chain A against the predicted model P11172: TM-score 1.00, RMSD 0.18 Å
- 3G3D chain A against the predicted model P11172: TM-score 1.00, RMSD 0.18 Å
- 2QCE chain A against the predicted model P11172: TM-score 1.00, RMSD 0.19 Å
- 2QCE chain A against the predicted model P11172: TM-score 1.00, RMSD 0.19 Å
- 3EWY chain A against the predicted model P11172: TM-score 1.00, RMSD 0.19 Å
- 3EWY chain A against the predicted model P11172: TM-score 1.00, RMSD 0.19 Å
- 3MI2 chain A against the predicted model P11172: TM-score 1.00, RMSD 0.19 Å
Elsewhere
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