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Ligand · UFT

UFT · 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate)

UFT, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate) (C9 H12 F N2 O8 P, 326.2 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
UFT
Formula
C9 H12 F N2 O8 P
Class
ligand
Structures
5
PDB entries
3

Binding sites

UFT in 5 structures; the first of them:

  • 3MO7 · Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified… · UFT A3000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, GLU181, MET182 and 9 more
  • 3MWA · Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase… · UFT A1000 · binds ASP23, LYS102, ASN104, ASP136, LYS138, THR194, THR195, VAL240 and 12 more
  • 3MO7 · Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified… · UFT A3000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, GLU181, MET182 and 9 more
  • 3MWA · Crystal structure of plasmodium falciparum orotidine 5'-monophosphate decarboxylase… · UFT A1000 · binds ASP23, LYS102, ASN104, ASP136, LYS138, THR194, THR195, VAL240 and 12 more
  • 7N33 · SARS-cov-2 NSP15 endoribonuclease pre-cleavage state · UFT G401 · binds GLN245, HIS250, LYS290, VAL292, CYS293, SER294, THR341, TYR343 and 2 more

Residues it binds most

LYS 12, THR 10, ASP 6, ILE 6, VAL 12, PRO 12, SER 8, GLN 9, ASN 4, HIS 8 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion
  • GOL · Glycerol
  • PEG · Di(hydroxyethyl)ether

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