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Ligand · 5FU

5FU · 5-fluoro-uridine-5'-monophosphate

5FU, 5-fluoro-uridine-5'-monophosphate (C9 H12 F N2 O9 P, 342.2 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
5FU
Formula
C9 H12 F N2 O9 P
Class
ligand
Structures
16
PDB entries
8

Binding sites

5FU in 16 structures; the first of them:

  • 2QCF · Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn… · 5FU A501 · binds SER257, ASP259, LYS281, HIS283, ASN312, LYS314, ILE368, GLU370 and 12 more
  • 2VP6 · Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila… · 5FU A1211 · binds ILE29, GLU52, TRP57, LEU66, MET69, TYR70, PHE80, GLN81 and 7 more
  • 3G1V · Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from… · 5FU A501 · binds ALA18, ASP20, LYS42, LYS72, LEU123, GLU125, MET126, SER127 and 13 more
  • 3G3D · Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified… · 5FU A3000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, GLU181 and 14 more
  • 3G3M · Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified… · 5FU A1000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, GLU181 and 12 more
  • 3MW7 · Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with… · 5FU A292 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, MET182 and 12 more
  • 3SGU · Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate… · 5FU A1000 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 3SW6 · Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate… · 5FU A1000 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 2QCF · Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (ASP312ASN… · 5FU A501 · binds SER257, ASP259, LYS281, HIS283, ASN312, LYS314, ILE368, GLU370 and 12 more
  • 2VP6 · Structural studies of nucleoside analog and feedback inhibitor binding to drosophila… · 5FU A1211 · binds ILE29, GLU52, TRP57, LEU66, MET69, TYR70, PHE80, GLN81 and 7 more
  • 3G1V · Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from… · 5FU A501 · binds ALA18, ASP20, LYS42, LYS72, LEU123, GLU125, MET126, SER127 and 13 more
  • 3G3D · Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified… · 5FU A3000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, GLU181 and 14 more
  • 3G3M · Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified… · 5FU A1000 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, GLU181 and 12 more
  • 3MW7 · Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with… · 5FU A292 · binds SER68, ASP70, LYS92, HIS94, ASP123, LYS125, ILE179, MET182 and 12 more
  • 3SGU · Crystal structure of methanothermobacter thermautotrophicus orotidine 5'-monophosphate… · 5FU A1000 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 3SW6 · Crystal structure of methanothermobacter thermautotrophicus orotidine 5'-monophosphate… · 5FU A1000 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more

Residues it binds most

ILE 36, MET 36, VAL 36, GLU 34, ASP 20, LYS 20, TYR 36, ARG 36, GLN 36, GLY 20 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • CL · Chloride ion

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