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Ligand · 6CN

6CN · 6-cyanouridine 5'-phosphate

6CN, 6-cyanouridine 5'-phosphate (C10 H12 N3 O9 P, 349.2 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
6CN
Formula
C10 H12 N3 O9 P
Class
ligand
Structures
14
PDB entries
7

Binding sites

6CN in 14 structures; the first of them:

  • 2ZZ1 · Snapshot of the reaction from 6-CN-UMP to BMP catalyzed by Orotidine Monophosphate… · 6CN A303 · binds ALA18, ASP20, LYS42, ASP70, LYS72, ILE96, LEU123, GLU125 and 15 more
  • 2ZZ2 · Orotidine Monophosphate Decarboxylase K72A mutant from M. thermoautotrophicum complexed… · 6CN A301 · binds ALA18, ASP20, LYS42, ASP70, ILE96, LEU123, GLU125, MET126 and 15 more
  • 2ZZ3 · Covalent complex of orotidine monophosphate decarboxylase D70A mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, LYS72, LEU123, GLU125, MET126, SER127 and 12 more
  • 2ZZ4 · Covalent complex of orotidine monophosphate decarboxylase D75N mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 13 more
  • 2ZZ5 · Orotidine Monophosphate Deacarboxylase D70A/K72A double mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, ILE96, LEU123, GLU125, MET126, SER127 and 13 more
  • 3EX1 · human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP · 6CN B481 · binds ASP317, ILE318, THR321, SER257, ASP259, LYS281, HIS283, ASP312 and 14 more
  • 3EX2 · human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP · 6CN A481 · binds SER257, ASP259, LYS281, HIS283, ASP312, LYS314, GLU370, MET371 and 14 more
  • 2ZZ1 · Snapshot of the reaction from 6-cn-ump to bmp catalyzed by orotidine monophosphate… · 6CN A303 · binds ALA18, ASP20, LYS42, ASP70, LYS72, ILE96, LEU123, GLU125 and 15 more
  • 2ZZ2 · Orotidine monophosphate decarboxylase K72A mutant from M. thermoautotrophicum complexed… · 6CN A301 · binds ALA18, ASP20, LYS42, ASP70, ILE96, LEU123, GLU125, MET126 and 15 more
  • 2ZZ3 · Covalent complex of orotidine monophosphate decarboxylase D70A mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, LYS72, LEU123, GLU125, MET126, SER127 and 12 more
  • 2ZZ4 · Covalent complex of orotidine monophosphate decarboxylase D75N mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 13 more
  • 2ZZ5 · Orotidine monophosphate deacarboxylase D70A/K72A double mutant from M.… · 6CN A301 · binds ALA18, ASP20, LYS42, ILE96, LEU123, GLU125, MET126, SER127 and 13 more
  • 3EX1 · Human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-ump, converted to ump · 6CN B481 · binds ASP317, ILE318, THR321, SER257, ASP259, LYS281, HIS283, ASP312 and 14 more
  • 3EX2 · Human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano- ump · 6CN A481 · binds SER257, ASP259, LYS281, HIS283, ASP312, LYS314, GLU370, MET371 and 14 more

Residues it binds most

ILE 26, ASP 26, VAL 26, LYS 26, ALA 20, GLY 26, SER 26, ARG 26, GLN 26, GLU 26 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • BMP · 6-hydroxyuridine-5'-phosphate
  • U5P · Uridine-5'-monophosphate

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