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Ligand · UP6

UP6 · 6-aza uridine 5'-monophosphate

UP6, 6-aza uridine 5'-monophosphate (C8 H12 N3 O9 P, 325.2 g/mol), in the MolNFT structures on GenesisL1: bound in 48 records (24 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
UP6
Formula
C8 H12 N3 O9 P
Class
ligand
Structures
48
PDB entries
24

Binding sites

UP6 in 48 structures; the first of them:

  • 1DVJ · Crystal structure of orotidine monophosphate decarboxylase complexed with 6-azaump · UP6 A5001 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 1KLY · Orotidine monophosphate decarboxylase D70G mutant complexed with 6-azaUMP · UP6 A2001 · binds ALA18, ASP20, LYS42, LYS72, LEU123, GLU125, MET126, SER127 and 10 more
  • 1KM0 · Crystal structure of orotidine monophosphate decarboxylase mutant D70N complexed with… · UP6 A5001 · binds ALA18, ASP20, LYS42, ASN70, LYS72, LEU123, GLU125, MET126 and 13 more
  • 1KM1 · Orotidine monophosphate decarboxylase mutant S127A crystal structure · UP6 A5001 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 14 more
  • 1KM2 · crystal structure of orotidine monophosphate mutant Q185A with 6-azaUMP · UP6 A2001 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 1KM3 · crystal structure of ODCase mutant K42A complexed with 6-azaUMP · UP6 A2001 · binds ALA18, ASP20, ASP70, LYS72, LEU123, GLU125, MET126, SER127 and 10 more
  • 1KM5 · Crystal structure of ODCase mutant D75N complexed with 6-azaUMP · UP6 A2001 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 11 more
  • 1LOS · crystal structure of orotidine monophosphate decarboxylase mutant deltaR203A complexed… · UP6 A5001 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 10 more
  • 2GUU · crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with… · UP6 A5203 · binds ASP41, LYS133, ASN135, ASP167, LYS169, THR225, THR226, VAL271 and 8 more
  • 3G1A · Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 14 more
  • 3G24 · Crystal structure of the mutant D70N of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASN70, LYS72, LEU123, GLU125, MET126 and 13 more
  • 3GDL · Crystal structure of the orotidine 5'-monophosphate decarboxylase from Saccharomyces… · UP6 A301 · binds SER35, ASP37, LYS59, HIS61, ASP91, LYS93, GLU152, LEU153 and 13 more
  • 3GDT · Crystal structure of the D91N mutant of the orotidine 5'-monophosphate decarboxylase from… · UP6 A301 · binds SER35, LYS59, HIS61, ASN91, LYS93, SER154, PRO202, GLY203 and 4 more
  • 3LLD · Crystal structure of the mutant S127G of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 14 more
  • 3LLF · Crystal structure of the mutant S127P of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 14 more
  • 3NQ6 · Crystal structure of the mutant P180A of orotidine 5'-monophosphate decarboxylase from… · UP6 A301 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, GLU125, MET126 and 14 more
  • 3PBU · Crystal structure of the mutant I96S of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, MET126, SER127 and 12 more
  • 3PBV · Crystal structure of the mutant I96T of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, LEU123, MET126, SER127 and 12 more
  • 3PBW · Crystal structure of the mutant L123N of orotidine 5'-monophosphate decarboxylase from… · UP6 A229 · binds ALA18, ASP20, LYS42, ASP70, LYS72, ASN123, GLU125, MET126 and 14 more

Residues it binds most

ASP 92, LYS 100, VAL 96, ALA 86, ILE 95, GLY 100, PRO 96, SER 82, TYR 94, ARG 92 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • CL · Chloride ion
  • MG · Magnesium ion
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • PRO · Proline

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