MolNFT v1 · #184441 · protein + RNA
The U2 part of saccharomyces cerevisiae spliceosomal pre-a complex (delta bs-a ACT1)
7OQB · U2 snrnp component HSH155: “The U2 part of saccharomyces cerevisiae spliceosomal pre-a complex (delta bs-a ACT1)”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #184441 on GenesisL1: 3D structure, binding sites…
- PDB
- 7OQB
- Type
- protein + RNA
- Length
- 4,719 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U2 snrnp component HSH155; ACT1 pre-mRNA (delta-bs-a); Pre-mRNA-splicing factor PRP11…
- UniProt
- P49955, Q07350, P32524, P19736, Q06835, Q02554, Q04693, Q99181, P0C074, Q08963, P40567, P40018, Q02260, Q06217, P43321, Q12330, P54999, P40204, P21372
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 21 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| O | U2 snrnp component HSH155 | protein | 812 | 73% helix, 0% strand | P49955 |
| I | ACT1 pre-mRNA (delta-bs-a) | rna | 23 | — | — |
| U | Pre-mRNA-splicing factor PRP11 | protein | 188 | 17% helix, 23% strand | Q07350 |
| V | Pre-mRNA-splicing factor PRP21 | protein | 103 | 63% helix, 0% strand | P32524 |
| T | Pre-mRNA-splicing factor PRP9 | protein | 462 | 58% helix, 3% strand | P19736 |
| S | Pre-mRNA-splicing factor RDS3 | protein | 92 | 17% helix, 16% strand | Q06835 |
| Q | Cold sensitive U2 snrna suppressor 1 | protein | 220 | 35% helix, 5% strand | Q02554 |
| P | Pre-mRNA-splicing factor RSE1 | protein | 1186 | 8% helix, 42% strand | Q04693 |
| R | Protein HSH49 | protein | 173 | 29% helix, 32% strand | Q99181 |
| Z | RDS3 complex subunit 10 | protein | 83 | 76% helix, 0% strand | P0C074 |
| W | U2 small nuclear ribonucleoprotein a' | protein | 170 | 22% helix, 13% strand | Q08963 |
| Y | U2 small nuclear ribonucleoprotein B'' | protein | 84 | 26% helix, 23% strand | P40567 |
| s | Small nuclear ribonucleoprotein-associated protein B | protein | 65 | 0% helix, 52% strand | P40018 |
| t | Small nuclear ribonucleoprotein sm D1 | protein | 72 | 13% helix, 54% strand | Q02260 |
| u | Small nuclear ribonucleoprotein sm D2 | protein | 92 | 22% helix, 49% strand | Q06217 |
| v | Small nuclear ribonucleoprotein sm D3 | protein | 82 | 16% helix, 46% strand | P43321 |
| w | Small nuclear ribonucleoprotein E | protein | 77 | 14% helix, 48% strand | Q12330 |
| x | Small nuclear ribonucleoprotein F | protein | 73 | 15% helix, 58% strand | P54999 |
| y | Small nuclear ribonucleoprotein G | protein | 75 | 8% helix, 52% strand | P40204 |
| p | Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | protein | 444 | 46% helix, 15% strand | P21372 |
| 2 | U2 snrna | rna | 143 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1144 | 0.85 | 0.87 | 143 | empty |
| 2 | 984 | 0.82 | 0.83 | 111 | empty |
| 3 | 1180 | 0.82 | 0.83 | 116 | empty |
| 4 | 777 | 0.81 | 0.84 | 121 | empty |
| 5 | 410 | 0.80 | 0.89 | 83 | empty |
Interfaces
49 interfaces between chains.
- O–Q · 1076 Ų buried · 0 hydrogen bonds · protein-protein
- I–2 · 752 Ų buried · 64 hydrogen bonds · nucleic-nucleic
- Q–P · 594 Ų buried · 3 hydrogen bonds · protein-protein
- Y–2 · 567 Ų buried · 3 hydrogen bonds · protein-nucleic
- P–Z · 563 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7OQB · The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) · the same entry in another collection · chain W against W, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49955
- Every structure of UniProt Q07350
- Every structure of UniProt P32524
- Every structure of UniProt P19736
- Every structure of UniProt Q06835
- Every structure of UniProt Q02554
- Every structure of UniProt Q04693
- Every structure of UniProt Q99181
- Every structure of UniProt P0C074
- Every structure of UniProt Q08963
- Every structure of UniProt P40567
- Every structure of UniProt P40018
- Every structure of UniProt Q02260
- Every structure of UniProt Q06217
- Every structure of UniProt P43321
- Every structure of UniProt Q12330
- Every structure of UniProt P54999
- Every structure of UniProt P40204
- Every structure of UniProt P21372
- Elsewhere: RCSB PDB 7OQB · PDBe 7OQB · UniProt P49955 · UniProt Q07350 · UniProt P32524 · UniProt P19736 · UniProt Q06835 · UniProt Q02554 · UniProt Q04693 · UniProt Q99181 · UniProt P0C074 · UniProt Q08963 · UniProt P40567 · UniProt P40018 · UniProt Q02260 · UniProt Q06217 · UniProt P43321 · UniProt Q12330 · UniProt P54999 · UniProt P40204 · UniProt P21372
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