MolNFT v1 · #176572 · protein
Bovine 20S immunoproteasome
7DR7 · Proteasome subunit alpha type-7: “Bovine 20S immunoproteasome”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #176572 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DR7
- Type
- protein
- Length
- 6,220 residues
- Chains
- 28
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha type-7; Proteasome subunit alpha type-5; Proteasome subunit…
- EC
- 3.4.25.1
- UniProt
- Q3ZBG0, Q5E987, Q3T0X5, Q58DU5, Q2YDE4, Q3T0Y5, Q3ZCK9, P33672, Q5E9K0, Q2TBX6, Q3T108, Q3SZC2, Q3T0T1, Q3T112
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 18 distinct chains · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | Proteasome subunit alpha type-7 | protein | 232 | 35% helix, 23% strand | Q3ZBG0 |
| B, P | Proteasome subunit alpha type-5 | protein | 234 | 33% helix, 25% strand | Q5E987 |
| C, Q | Proteasome subunit alpha type-1 | protein | 235 | 34% helix, 21% strand | Q3T0X5 |
| D, R | Proteasome subunit alpha type-3 | protein | 240 | 36% helix, 25% strand | Q58DU5 |
| E | Proteasome subunit alpha type-6 | protein | 244 | 38% helix, 24% strand | Q2YDE4 |
| F | Proteasome subunit alpha type-2 | protein | 231 | 35% helix, 25% strand | Q3T0Y5 |
| G, N | Proteasome subunit alpha type-4 | protein | 246 | 39% helix, 23% strand | Q3ZCK9 |
| H, S | Proteasome subunit beta type-3 (EC 3.4.25.1) | protein | 204 | 30% helix, 28% strand | P33672 |
| I | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 198 | 32% helix, 32% strand | Q5E9K0 |
| J, U | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 213 | 30% helix, 30% strand | Q2TBX6 |
| K | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 216 | 32% helix, 30% strand | Q3T108 |
| L | Proteasome subunit alpha type-6 | protein | 243 | 38% helix, 25% strand | Q2YDE4 |
| M | Proteasome subunit alpha type-2 | protein | 229 | 35% helix, 26% strand | Q3T0Y5 |
| T | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 197 | 32% helix, 32% strand | Q5E9K0 |
| V | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 216 | 33% helix, 29% strand | Q3T108 |
| W, Z | Proteasome subunit beta type-9 (EC 3.4.25.1) | protein | 199 | 31% helix, 29% strand | Q3SZC2 |
| X, 1 | Proteasome subunit beta type-10 (EC 3.4.25.1) | protein | 219 | 28% helix, 30% strand | Q3T0T1 |
| Y, 2 | Proteasome subunit beta type-8 (EC 3.4.25.1) | protein | 201 | 34% helix, 28% strand | Q3T112 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 666 | 0.81 | 0.85 | 67 | empty |
| 2 | 1052 | 0.76 | 0.78 | 107 | empty |
| 3 | 1160 | 0.76 | 0.78 | 100 | empty |
| 4 | 974 | 0.75 | 0.78 | 92 | empty |
| 5 | 935 | 0.75 | 0.78 | 98 | empty |
Interfaces
86 interfaces between chains.
- S–1 · 1713 Ų buried · 23 hydrogen bonds · protein-protein
- H–X · 1651 Ų buried · 19 hydrogen bonds · protein-protein
- M–N · 1577 Ų buried · 17 hydrogen bonds · protein-protein
- F–G · 1562 Ų buried · 14 hydrogen bonds · protein-protein
- L–M · 1466 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7DR7 · bovine 20S immunoproteasome · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3ZBG0
- Every structure of UniProt Q5E987
- Every structure of UniProt Q3T0X5
- Every structure of UniProt Q58DU5
- Every structure of UniProt Q2YDE4
- Every structure of UniProt Q3T0Y5
- Every structure of UniProt Q3ZCK9
- Every structure of UniProt P33672
- Every structure of UniProt Q5E9K0
- Every structure of UniProt Q2TBX6
- Every structure of UniProt Q3T108
- Every structure of UniProt Q3SZC2
- Every structure of UniProt Q3T0T1
- Every structure of UniProt Q3T112
- Elsewhere: RCSB PDB 7DR7 · PDBe 7DR7 · UniProt Q3ZBG0 · UniProt Q5E987 · UniProt Q3T0X5 · UniProt Q58DU5 · UniProt Q2YDE4 · UniProt Q3T0Y5 · UniProt Q3ZCK9 · UniProt P33672 · UniProt Q5E9K0 · UniProt Q2TBX6 · UniProt Q3T108 · UniProt Q3SZC2 · UniProt Q3T0T1 · UniProt Q3T112
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