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MolNFT v1 · #162949 · protein + DNA

Structure of the core tfiih-xpa-DNA complex

6RO4: “Structure of the core tfiih-xpa-DNA complex”. Electron microscopy, 2 ligands (SF4, ZN). MolNFT v1 #162949 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6RO4
Type
protein + DNA
Length
2,396 residues
Chains
9
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P19447, Q6ZYL4, P18074, Q13889, Q13888, Q92759, P23025
Ligands
SF4, ZN

Structure

electron microscopy · 9 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
J—dna19——
K—dna28——
A—protein575—P19447
F—protein62—Q6ZYL4
B—protein675—P18074
E—protein237—Q13889
D—protein280—Q13888
C—protein386—Q92759
G—protein134—P23025

Ligands and binding sites

  • SF4 · Iron/sulfur cluster · ligand · chains B
  • ZN · Zinc ion · metal · 6 copies · chains E, D, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6RO4 · Structure of the core TFIIH-XPA-DNA complex · the same entry in another collection · chain G against G, TM-score 1.00
  • P18074 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain B against A, TM-score 0.98
  • Q13889 · AlphaFold monomer V2.0 prediction for general transcription factor iih subunit 3 (Q13889) · a predicted model of the same protein · chain E against A, TM-score 0.94
  • P19447 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain A against A, TM-score 0.91

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