UniProt P23025
DNA repair protein complementing XP-A cells (P23025)
DNA repair protein complementing XP-A cells (UniProt P23025): 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P23025
- Protein
- DNA repair protein complementing XP-A cells
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 13 · 3 records with a druggable one
Structures
16 records of P23025 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D4U | Interactions of human nucleotide excision repair protein xpa with RPA70 and DNA: chemical shift… | solution nmr | A | — | — |
| 1D4U | Interactions of human nucleotide excision repair protein xpa with RPA70 and DNA: chemical shift… | solution nmr | A | — | — |
| 1XPA | Solution structure of the DNA-and rpa-binding domain of the human repair factor xpa, NMR, 1… | solution nmr | A | — | — |
| 1XPA | Solution structure of the DNA-and rpa-binding domain of the human repair factor xpa, NMR, 1… | solution nmr | A | — | — |
| 2JNW | Solution structure of a ERCC1-XPA heterodimer | solution nmr | B | — | — |
| 2JNW | Solution structure of a ERCC1-xpa heterodimer | solution nmr | B | — | — |
| 6J44 | Crystal structure of the redefined DNA-binding domain of human XPA | x-ray diffraction | A | ZN | — |
| 6J44 | Crystal structure of the redefined DNA-binding domain of human xpa | x-ray diffraction | A | ZN | — |
| 6LAE | Crystal structure of the DNA-binding domain of human xpa in complex with DNA | x-ray diffraction | A, B | ZN | — |
| 6RO4 | Structure of the core TFIIH-XPA-DNA complex | electron microscopy | G | ZN | — |
| 6RO4 | Structure of the core tfiih-xpa-DNA complex | electron microscopy | G | ZN | — |
| 7AD8 | Core tfiih-xpa-DNA complex with modelled P62 subunit | electron microscopy | G | ZN | — |
| 8EBT | XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5) | electron microscopy | K | ZN | 3 (best 0.77) |
| 8EBU | XPC release from Core7-XPA-DNA (Cy5) | electron microscopy | K | ZN | 5 (best 0.81) |
| 8EBY | XPC release from Core7-XPA-DNA (AP) | electron microscopy | K | ZN | 5 (best 0.72) |
| P23025 | AlphaFold monomer V2.0 prediction for DNA repair protein complementing xp-a cells (P23025) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 9 records
Experiment against prediction
- 6J44 chain A against the predicted model P23025: TM-score 0.97, RMSD 0.82 Å
- 6J44 chain A against the predicted model P23025: TM-score 0.97, RMSD 0.82 Å
- 6LAE chain A against the predicted model P23025: TM-score 0.93, RMSD 1.21 Å
- 7AD8 chain G against the predicted model P23025: TM-score 0.83, RMSD 2.42 Å
- 6RO4 chain G against the predicted model P23025: TM-score 0.83, RMSD 2.42 Å
- 6RO4 chain G against the predicted model P23025: TM-score 0.83, RMSD 2.42 Å
- 1XPA chain A against the predicted model P23025: TM-score 0.75, RMSD 2.89 Å
- 1XPA chain A against the predicted model P23025: TM-score 0.75, RMSD 2.89 Å
- 8EBU chain K against the predicted model P23025: TM-score 0.71, RMSD 2.17 Å
- 8EBT chain K against the predicted model P23025: TM-score 0.69, RMSD 2.52 Å
Elsewhere
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