UniProt P19447
TFIIH basal transcription factor complex helicase XPB subunit (P19447)
TFIIH basal transcription factor complex helicase XPB subunit (UniProt P19447), EC 3.6.4.12: 30 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 30 pockets. Binding sites, druggability and experiment…
- UniProt
- P19447
- Protein
- TFIIH basal transcription factor complex helicase XPB subunit
- EC
- 3.6.4.12
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 30 · 4 records with a druggable one
Structures
31 records of P19447 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4ERN | Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1.80 A | x-ray diffraction | A | — | — |
| 4ERN | Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1.80 a | x-ray diffraction | A | — | — |
| 5IVW | Human core tfiih bound to DNA within the pic | electron microscopy | V | — | — |
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | V | — | 1 (best 0.83) |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | V | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | V | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | V | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | V | — | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | V | — | — |
| 5OF4 | The cryo-EM structure of human TFIIH | electron microscopy | A | — | 9 (best 0.78) |
| 5OF4 | The cryo-EM structure of human tfiih | electron microscopy | A | — | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | 7 | — | — |
| 6O9M | Structure of the human apo tfiih | electron microscopy | 7 | — | — |
| 6RO4 | Structure of the core TFIIH-XPA-DNA complex | electron microscopy | A | — | — |
| 6RO4 | Structure of the core tfiih-xpa-DNA complex | electron microscopy | A | — | — |
| 7AD8 | Core tfiih-xpa-DNA complex with modelled P62 subunit | electron microscopy | A | — | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | 6 | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | 6 | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | 6 | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | 7 | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | 7 | — | — |
| 7NVV | XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3) | electron microscopy | 7 | ADP, MG, BEF | — |
| 7NVV | Xpb-containing part of tfiih in a post-translocated state (with ADP- BEF3) | electron microscopy | 7 | ADP, MG, BEF | — |
| 7NVW | Tfiih in a pre-translocated state (without ADP-BEF3) | electron microscopy | 7 | — | — |
| 7NVX | Tfiih in a post-translocated state (with ADP-BEF3) | electron microscopy | 7 | ADP, MG, BEF | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | 7 | — | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | 7 | — | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 7 | ADP, MG, BEF | — |
| 8EBU | XPC release from Core7-XPA-DNA (Cy5) | electron microscopy | A | — | 11 (best 0.83) |
| 8EBW | Initial DNA-lesion (AP) binding by XPC and TFIIH complex2 | electron microscopy | A | — | 9 (best 0.82) |
| P19447 | AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase… | predicted | A | — | — |
Ligands
Experiment against prediction
- 4ERN chain A against the predicted model P19447: TM-score 0.99, RMSD 0.57 Å
- 4ERN chain A against the predicted model P19447: TM-score 0.99, RMSD 0.57 Å
- 5OF4 chain A against the predicted model P19447: TM-score 0.94, RMSD 1.99 Å
- 5OF4 chain A against the predicted model P19447: TM-score 0.94, RMSD 1.99 Å
- 7AD8 chain A against the predicted model P19447: TM-score 0.91, RMSD 2.58 Å
- 6RO4 chain A against the predicted model P19447: TM-score 0.91, RMSD 2.59 Å
- 6RO4 chain A against the predicted model P19447: TM-score 0.91, RMSD 2.59 Å
- 7NVY chain 7 against the predicted model P19447: TM-score 0.91, RMSD 2.62 Å
- 7NVR chain 7 against the predicted model P19447: TM-score 0.91, RMSD 2.62 Å
- 7NVR chain 7 against the predicted model P19447: TM-score 0.91, RMSD 2.62 Å
Elsewhere
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