UniProt Q13889
General transcription factor IIH subunit 3 (Q13889)
General transcription factor IIH subunit 3 (UniProt Q13889): 33 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q13889
- Protein
- General transcription factor IIH subunit 3
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 5 records with a druggable one
Structures
34 records of Q13889 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IVW | Human core TFIIH bound to DNA within the PIC | electron microscopy | 3 | — | 4 (best 0.77) |
| 5IVW | Human core tfiih bound to DNA within the pic | electron microscopy | 3 | — | — |
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | 3 | — | — |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | 3 | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | 3 | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | 3 | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | 3 | — | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | 3 | — | — |
| 5O85 | p34-p44 complex | x-ray diffraction | A, C | — | — |
| 5O85 | P34-P44 complex | x-ray diffraction | A, C | — | — |
| 5OF4 | The cryo-EM structure of human TFIIH | electron microscopy | F | — | 2 (best 0.80) |
| 5OF4 | The cryo-EM structure of human tfiih | electron microscopy | F | — | — |
| 6NMI | Cryo-EM structure of the human TFIIH core complex | electron microscopy | F | ZN | — |
| 6NMI | Cryo-EM structure of the human tfiih core complex | electron microscopy | F | ZN | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | 4 | ZN | — |
| 6O9M | Structure of the human apo tfiih | electron microscopy | 4 | ZN | — |
| 6RO4 | Structure of the core TFIIH-XPA-DNA complex | electron microscopy | E | ZN | — |
| 6RO4 | Structure of the core tfiih-xpa-DNA complex | electron microscopy | E | ZN | — |
| 7AD8 | Core tfiih-xpa-DNA complex with modelled P62 subunit | electron microscopy | E | ZN | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | 3 | ZN | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | 3 | ZN | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | 3 | ZN | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | 4 | ZN | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | 4 | ZN | — |
| 7NVW | Tfiih in a pre-translocated state (without ADP-BEF3) | electron microscopy | 4 | ZN | — |
| 7NVX | Tfiih in a post-translocated state (with ADP-BEF3) | electron microscopy | 4 | ZN | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | 4 | ZN | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | 4 | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 4 | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 4 | ZN | — |
| 8EBU | XPC release from Core7-XPA-DNA (Cy5) | electron microscopy | F | ZN | 3 (best 0.68) |
| 8EBW | Initial DNA-lesion (AP) binding by XPC and TFIIH complex2 | electron microscopy | F | ZN | 3 (best 0.73) |
| 8WAQ | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II… | electron microscopy | 3 | ZN | — |
| Q13889 | AlphaFold monomer V2.0 prediction for general transcription factor iih subunit 3 (Q13889) | predicted | A | — | 3 (best 0.62) |
Ligands
- ZN · Zinc ion · in 21 records
Experiment against prediction
- 5O85 chain A against the predicted model Q13889: TM-score 0.98, RMSD 0.78 Å
- 5O85 chain A against the predicted model Q13889: TM-score 0.98, RMSD 0.78 Å
- 5O85 chain C against the predicted model Q13889: TM-score 0.97, RMSD 1.12 Å
- 5O85 chain C against the predicted model Q13889: TM-score 0.97, RMSD 1.12 Å
- 8EBU chain F against the predicted model Q13889: TM-score 0.95, RMSD 1.75 Å
- 6RO4 chain E against the predicted model Q13889: TM-score 0.94, RMSD 1.62 Å
- 6RO4 chain E against the predicted model Q13889: TM-score 0.94, RMSD 1.62 Å
- 7AD8 chain E against the predicted model Q13889: TM-score 0.94, RMSD 1.60 Å
- 5OF4 chain F against the predicted model Q13889: TM-score 0.93, RMSD 1.80 Å
- 5OF4 chain F against the predicted model Q13889: TM-score 0.93, RMSD 1.80 Å
Elsewhere
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