UniProt P18074
General transcription and DNA repair factor IIH helicase subunit XPD (P18074)
General transcription and DNA repair factor IIH helicase subunit XPD (UniProt P18074), EC 3.6.4.12: 25 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 14 pockets. Binding sites, druggability and…
- UniProt
- P18074
- Protein
- General transcription and DNA repair factor IIH helicase subunit XPD
- EC
- 3.6.4.12
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 14 · 2 records with a druggable one
Structures
26 records of P18074 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IVW | Human core tfiih bound to DNA within the pic | electron microscopy | W | — | — |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | W | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | W | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | W | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | W | — | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | W | — | — |
| 5OF4 | The cryo-EM structure of human tfiih | electron microscopy | B | SF4 | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | 0 | SF4 | — |
| 6O9M | Structure of the human apo tfiih | electron microscopy | 0 | SF4 | — |
| 6RO4 | Structure of the core TFIIH-XPA-DNA complex | electron microscopy | B | SF4 | — |
| 6RO4 | Structure of the core tfiih-xpa-DNA complex | electron microscopy | B | SF4 | — |
| 6TUN | Helicase domain complex | x-ray diffraction | A, B | CL | — |
| 7AD8 | Core tfiih-xpa-DNA complex with modelled P62 subunit | electron microscopy | B | SF4 | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | 7 | SF4 | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | 7 | SF4 | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | 7 | SF4 | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | 0 | SF4 | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | 0 | SF4 | — |
| 7NVW | Tfiih in a pre-translocated state (without ADP-BEF3) | electron microscopy | 0 | SF4 | — |
| 7NVX | Tfiih in a post-translocated state (with ADP-BEF3) | electron microscopy | 0 | SF4 | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | 0 | SF4 | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | 0 | SF4 | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 0 | SF4 | — |
| 8EBU | XPC release from Core7-XPA-DNA (Cy5) | electron microscopy | B | SF4 | 8 (best 0.81) |
| 8EBW | Initial DNA-lesion (AP) binding by XPC and TFIIH complex2 | electron microscopy | B | SF4 | 6 (best 0.77) |
| P18074 | AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih helicase… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8EBW chain B against the predicted model P18074: TM-score 0.99, RMSD 0.75 Å
- 7NVY chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.41 Å
- 7NVR chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.41 Å
- 7NVR chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.41 Å
- 7NVZ chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.41 Å
- 7NVW chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.42 Å
- 7NVX chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.44 Å
- 7NW0 chain 0 against the predicted model P18074: TM-score 0.98, RMSD 1.44 Å
- 7EGC chain 7 against the predicted model P18074: TM-score 0.98, RMSD 1.48 Å
- 6RO4 chain B against the predicted model P18074: TM-score 0.98, RMSD 1.48 Å
Elsewhere
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