AlphaFold monomer V2.0 prediction for general transcription factor iih subunit 3 (Q13889)

Structure

1 distinct chain · 36% helix, 17% strand (DSSP).

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 7ENA · TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) · an experimental structure of the same protein · chain A against 3, TM-score 0.81
• 6O9M · Structure of the human apo tfiih · an experimental structure of the same protein · chain A against 4, TM-score 0.81
• 6O9M · Structure of the human apo TFIIH · an experimental structure of the same protein · chain A against 4, TM-score 0.81
• 8EBU · XPC release from Core7-XPA-DNA (Cy5) · an experimental structure of the same protein · chain A against F, TM-score 0.80
• 8EBX · XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP) · an experimental structure of the same protein · chain A against F, TM-score 0.79
• 8EBT · XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5) · an experimental structure of the same protein · chain A against F, TM-score 0.79
• 8EBY · XPC release from Core7-XPA-DNA (AP) · an experimental structure of the same protein · chain A against F, TM-score 0.79
• 7LBM · Structure of the human Mediator-bound transcription pre-initiation complex · an experimental structure of the same protein · chain A against b, TM-score 0.79
• 6NMI · Cryo-EM structure of the human tfiih core complex · an experimental structure of the same protein · chain A against F, TM-score 0.79
• 6NMI · Cryo-EM structure of the human TFIIH core complex · an experimental structure of the same protein · chain A against F, TM-score 0.79
• 8GXQ · PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state · an experimental structure of the same protein · chain A against HE, TM-score 0.79
• 8GXS · PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state · an experimental structure of the same protein · chain A against HE, TM-score 0.79

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13889
• Elsewhere: UniProt Q13889 · AlphaFold DB Q13889