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Orc-open: human origin recognition complex (orc) in an open conformation

Analyse Orc-open: human origin recognition complex (orc) in an open conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7JPR
Type
protein
Length
2,045 residues
Chains
5
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q13415, Q13416, Q9UBD5, O43929, O43913
Ligands
ATP, MG

Structure

electron microscopy · 5 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein352—Q13415
B—protein307—Q13416
C—protein593—Q9UBD5
D—protein406—O43929
E—protein387—O43913

Ligands and binding sites

  • ATP · Adenosine-5'-triphosphate · ligand · 3 copies · chains A, D, E
  • MG · Magnesium ion · metal · 3 copies · chains A, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7JPR · ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation · the same entry in another collection · chain E against E, TM-score 1.00
  • Q13415 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 1 (Q13415) · a predicted model of the same protein · chain A against A, TM-score 0.98
  • O43929 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 4 (O43929) · a predicted model of the same protein · chain D against A, TM-score 0.94
  • Q9UBD5 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 3 (Q9UBD5) · a predicted model of the same protein · chain C against A, TM-score 0.89
  • O43913 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 5 (O43913) · a predicted model of the same protein · chain E against A, TM-score 0.88
  • Q13416 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 2 (Q13416) · a predicted model of the same protein · chain B against A, TM-score 0.67

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