UniProt O43929
Origin recognition complex subunit 4 (O43929)
Origin recognition complex subunit 4 (UniProt O43929): 22 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 108 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43929
- Protein
- Origin recognition complex subunit 4
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 108 · 13 records with a druggable one
Structures
23 records of O43929 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UJ7 | Structure of the active form of human Origin Recognition Complex ATPase motor module, complex… | x-ray diffraction | C, D | ATP, MG | 17 (best 0.88) |
| 5UJ7 | Structure of the active form of human origin recognition complex ATPase motor module, complex… | x-ray diffraction | C, D | ATP, MG | — |
| 5UJM | Structure of the active form of human Origin Recognition Complex and its ATPase motor module | electron microscopy | D | ATP, MG | 11 (best 0.86) |
| 5UJM | Structure of the active form of human origin recognition complex and its ATPase motor module | electron microscopy | D | ATP, MG | — |
| 7CTE | Human origin recognition complex, ORC2-5 | electron microscopy | D | ATP | — |
| 7CTF | Human origin recognition complex 1-5 State II | electron microscopy | D | ATP | 6 (best 0.84) |
| 7CTF | Human origin recognition complex 1-5 state II | electron microscopy | D | ATP | — |
| 7CTG | Human Origin Recognition Complex, ORC1-5 State I | electron microscopy | D | ATP | 8 (best 0.82) |
| 7CTG | Human origin recognition complex, ORC1-5 state I | electron microscopy | D | ATP | — |
| 7JPO | ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH | electron microscopy | D | ATP, MG | 10 (best 0.84) |
| 7JPO | Orc-O1AAA: human origin recognition complex (orc) with DYNAMIC/UNRESOLVED ORC2 wh | electron microscopy | D | ATP, MG | — |
| 7JPP | Orc-O2WH: human origin recognition complex (orc) with DYNAMIC/UNRESOLVED ORC1 aaa+ domain | electron microscopy | D | ATP, MG | — |
| 7JPQ | ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5 | electron microscopy | D | ATP, MG | 7 (best 0.84) |
| 7JPQ | Orc-O2-5: human origin recognition complex (orc) with subunits 2,3,4,5 | electron microscopy | D | ATP, MG | — |
| 7JPR | ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation | electron microscopy | D | ATP, MG | 8 (best 0.83) |
| 7JPR | Orc-open: human origin recognition complex (orc) in an open conformation | electron microscopy | D | ATP, MG | — |
| 7JPS | ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core | electron microscopy | D | ATP, MG | 12 (best 0.84) |
| 7JPS | Orc-DNA: human origin recognition complex (orc) with DNA bound in the core | electron microscopy | D | ATP, MG | — |
| 8S0C | H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | electron microscopy | D | AGS, MG | 8 (best 0.86) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | D | AGS, MG | 3 (best 0.86) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | D | AGS, MG | 7 (best 0.89) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | D | AGS, MG | 8 (best 0.86) |
| O43929 | AlphaFold monomer V2.0 prediction for origin recognition complex subunit 4 (O43929) | predicted | A | — | 3 (best 0.67) |
Ligands
Experiment against prediction
- 5UJ7 chain D against the predicted model O43929: TM-score 0.95, RMSD 1.71 Å
- 5UJ7 chain D against the predicted model O43929: TM-score 0.95, RMSD 1.71 Å
- 5UJM chain D against the predicted model O43929: TM-score 0.94, RMSD 1.83 Å
- 5UJM chain D against the predicted model O43929: TM-score 0.94, RMSD 1.83 Å
- 5UJ7 chain C against the predicted model O43929: TM-score 0.94, RMSD 1.83 Å
- 5UJ7 chain C against the predicted model O43929: TM-score 0.94, RMSD 1.83 Å
- 7JPR chain D against the predicted model O43929: TM-score 0.94, RMSD 1.92 Å
- 7JPR chain D against the predicted model O43929: TM-score 0.94, RMSD 1.92 Å
- 7JPO chain D against the predicted model O43929: TM-score 0.94, RMSD 1.93 Å
- 7JPO chain D against the predicted model O43929: TM-score 0.94, RMSD 1.93 Å
Elsewhere
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