MolNFT v1 · #175527 · protein
Human origin recognition complex, ORC2-5
7CTE · Origin recognition complex subunit 2: “Human origin recognition complex, ORC2-5”. Electron microscopy, 1 ligand (ATP), 20 pockets (best druggability 0.84). MolNFT v1 #175527 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7CTE
- Type
- protein
- Length
- 1,673 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Origin recognition complex subunit 2; Origin recognition complex subunit 3; Origin…
- UniProt
- Q13416, Q9UBD5, O43929, O43913
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 4 distinct chains · 52% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Origin recognition complex subunit 2 | protein | 302 | 44% helix, 10% strand | Q13416 |
| C | Origin recognition complex subunit 3 | protein | 592 | 58% helix, 4% strand | Q9UBD5 |
| D | Origin recognition complex subunit 4 | protein | 406 | 54% helix, 6% strand | O43929 |
| E | Origin recognition complex subunit 5 | protein | 373 | 47% helix, 8% strand | O43913 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.84 | 0.85 | 122 | ATP |
| 2 | 601 | 0.79 | 0.84 | 74 | empty |
| 3 | 640 | 0.78 | 0.83 | 64 | ATP |
| 4 | 658 | 0.76 | 0.82 | 77 | empty |
| 5 | 108 | 0.75 | 0.95 | 24 | empty |
Interfaces
6 interfaces between chains.
- B–C · 3184 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 2806 Ų buried · 19 hydrogen bonds · protein-protein
- C–E · 1850 Ų buried · 13 hydrogen bonds · protein-protein
- B–E · 1159 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 443 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7CTE · Human Origin Recognition Complex, ORC2-5 · the same entry in another collection · chain E against E, TM-score 1.00
- Q9UBD5 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 3 (Q9UBD5) · a predicted model of the same protein · chain C against A, TM-score 0.96
- O43913 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 5 (O43913) · a predicted model of the same protein · chain E against A, TM-score 0.94
- O43929 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 4 (O43929) · a predicted model of the same protein · chain D against A, TM-score 0.92
- Q13416 · AlphaFold monomer V2.0 prediction for origin recognition complex subunit 2 (Q13416) · a predicted model of the same protein · chain B against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13416
- Every structure of UniProt Q9UBD5
- Every structure of UniProt O43929
- Every structure of UniProt O43913
- Elsewhere: RCSB PDB 7CTE · PDBe 7CTE · UniProt Q13416 · UniProt Q9UBD5 · UniProt O43929 · UniProt O43913
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