UniProt Q13416
Origin recognition complex subunit 2 (Q13416)
Origin recognition complex subunit 2 (UniProt Q13416): 18 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13416
- Protein
- Origin recognition complex subunit 2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 34 · 6 records with a druggable one
Structures
19 records of Q13416 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5C8H | Crystal structure of ORC2 C-terminal domain | x-ray diffraction | A | — | — |
| 5UJ8 | Human Origin Recognition Complex subunits 2 and 3 | x-ray diffraction | E, F, G, H | — | — |
| 5UJ8 | Human origin recognition complex subunits 2 and 3 | x-ray diffraction | E, F, G, H | — | — |
| 5UJM | Structure of the active form of human Origin Recognition Complex and its ATPase motor module | electron microscopy | B | — | 5 (best 0.81) |
| 5UJM | Structure of the active form of human origin recognition complex and its ATPase motor module | electron microscopy | B | — | — |
| 7CTE | Human origin recognition complex, ORC2-5 | electron microscopy | B | — | — |
| 7CTF | Human origin recognition complex 1-5 state II | electron microscopy | B | — | — |
| 7CTG | Human origin recognition complex, ORC1-5 state I | electron microscopy | B | — | — |
| 7JPO | ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH | electron microscopy | B | K | 9 (best 0.74) |
| 7JPO | Orc-O1AAA: human origin recognition complex (orc) with DYNAMIC/UNRESOLVED ORC2 wh | electron microscopy | B | K | — |
| 7JPP | Orc-O2WH: human origin recognition complex (orc) with DYNAMIC/UNRESOLVED ORC1 aaa+ domain | electron microscopy | B | — | — |
| 7JPQ | Orc-O2-5: human origin recognition complex (orc) with subunits 2,3,4,5 | electron microscopy | B | — | — |
| 7JPR | Orc-open: human origin recognition complex (orc) in an open conformation | electron microscopy | B | — | — |
| 7JPS | Orc-DNA: human origin recognition complex (orc) with DNA bound in the core | electron microscopy | B | K | — |
| 8S0C | H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | electron microscopy | B | — | 6 (best 0.72) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | B | — | — |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | B | — | 4 (best 0.81) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | B | — | 4 (best 0.77) |
| Q13416 | AlphaFold monomer V2.0 prediction for origin recognition complex subunit 2 (Q13416) | predicted | A | — | 6 (best 0.52) |
Ligands
- K · Potassium ion · in 3 records
Experiment against prediction
- 8S0F chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.04 Å
- 8S0C chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.12 Å
- 8S0D chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.13 Å
- 7JPO chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.33 Å
- 7JPO chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.33 Å
- 7JPS chain B against the predicted model Q13416: TM-score 0.96, RMSD 1.32 Å
- 5UJ8 chain E against the predicted model Q13416: TM-score 0.93, RMSD 1.49 Å
- 5UJ8 chain E against the predicted model Q13416: TM-score 0.93, RMSD 1.49 Å
- 5C8H chain A against the predicted model Q13416: TM-score 0.93, RMSD 1.18 Å
- 8S0E chain B against the predicted model Q13416: TM-score 0.70, RMSD 2.05 Å
Elsewhere
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