GL1X · GenesisL1 explorer

Research workbench

Complex I inhibited by rotenone, closed

Analyse Complex I inhibited by rotenone, closed in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6ZKK
Type
protein
Length
8,227 residues
Chains
45
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
W5PUX0, W5NRY1, W5QB34, W5PB27, O78753, O78747, O78757, O78754, O78756, O78755, O78748, W5PAR2, W5QHN8, W5NQT7, W5PYA5, W5PE07, W5PI58, W5QAH8, W5PNX7, W5QC06, W5P0I2, B9VGZ9, W5QBF5, W5QFF9, W5NYM7, W5Q5T4, W5P9Q8, W5QF73, W5PZE3, W5P5V3, W5PGA3, W5PVD7, W5Q1B0, W5PWF1
Ligands
3PE, CDL, SF4, PC1, FES, ZMP, FMN, NAI, 970, NDP, AMP, MYR, K, ZN

Structure

electron microscopy · 45 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
1—protein430—W5PUX0
2—protein213—W5NRY1
3—protein688—W5QB34
4—protein430——
5—protein208—W5PB27
6—protein156——
9—protein176——
A—protein115—O78753
H—protein318—O78747
J—protein175—O78757
K—protein98—O78754
L—protein606—O78756
M—protein459—O78755
N—protein347—O78748
V—protein140—W5PAR2
W—protein139—W5QHN8
X—protein87—W5NQT7
Y—protein171—W5PYA5
Z—protein171——
a—protein44——
b—protein95——
c—protein126—W5PE07
d—protein340—W5PI58
e—protein86—W5QAH8
f—protein113—W5PNX7
g—protein114—W5QC06
h—protein96—W5P0I2
i—protein145—B9VGZ9
j—protein82—W5NQT7
k—protein320—W5QBF5
l—protein105—W5QFF9
m—protein80—W5NYM7
n—protein79—W5Q5T4
o—protein120—W5P9Q8
p—protein128—W5QF73
q—protein139——
r—protein99—W5PZE3
s—protein122—W5P5V3
t—protein177—W5PGA3
u—protein65—W5PVD7
v—protein155—W5Q1B0
w—protein101—W5PWF1
x—protein49——
y—protein50——
z—protein70——

Ligands and binding sites

  • 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 13 copies · chains 4, L, M, N, 6, H, i, A, m, J, q, z, K, v, n, V, l, p, o
  • CDL · Cardiolipin · ligand · 8 copies · chains L, V, p, M, W, w, N, Y, o, y, k, Z, r, h, i, z, x
  • SF4 · Iron/sulfur cluster · ligand · 6 copies · chains 1, 3, 4, 6, 9
  • PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 5 copies · chains 6, A, H, d, 4, 9, m, L, M, r, w, N, V
  • FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains 2, 3
  • ZMP · S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate · ligand · 2 copies · chains X, t, g, j
  • FMN · Flavin mononucleotide · ligand · chains 1
  • NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains 1
  • 970 · (2r,6as,12as)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12, 12A-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6ah)-one · ligand · chains 4, 6
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains 6, d
  • AMP · Adenosine monophosphate · ligand · chains k
  • MYR · Myristic acid · ligand · chains L, s, v
  • K · Potassium ion · metal · chains 3
  • ZN · Zinc ion · metal · chains b

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6ZKK · Complex I inhibited by rote , closed · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.