UniProt O78756
NADH-ubiquinone oxidoreductase chain 5 (O78756)
NADH-ubiquinone oxidoreductase chain 5 (UniProt O78756), EC 7.1.1.2: 38 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 88 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O78756
- Protein
- NADH-ubiquinone oxidoreductase chain 5
- EC
- 7.1.1.2
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 88 · 13 records with a druggable one
Structures
39 records of O78756 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LNK | Entire ovine respiratory complex I | electron microscopy | L | CDL | — |
| 5LNK | Entire ovine respiratory complex I | electron microscopy | L | CDL | — |
| 6ZKA | Membrane domain of open complex I during turnover | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | L | 3PE, PC1, CDL, MYR | 9 (best 0.88) |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKC | Complex I during turnover, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | 6 (best 0.88) |
| 6ZKC | Complex I during turnover, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKD | Complex I during turnover, open1 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.88) |
| 6ZKD | Complex I during turnover, OPEN1 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKE | Complex I during turnover, OPEN2 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKF | Complex I during turnover, open3 | electron microscopy | L | 3PE, PC1, CDL, MYR | 6 (best 0.89) |
| 6ZKF | Complex I during turnover, OPEN3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKG | Complex I with NADH, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | 6 (best 0.88) |
| 6ZKG | Complex I with NADH, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKH | Complex I with NADH, open1 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.88) |
| 6ZKH | Complex I with NADH, OPEN1 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKI | Complex I with NADH, OPEN2 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKJ | Complex I with NADH, OPEN3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKK | Complex I inhibited by rotenone, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKL | Complex I inhibited by rote , open1 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.88) |
| 6ZKL | Complex I inhibited by rotenone, OPEN1 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKM | Complex I inhibited by rotenone, OPEN2 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKN | Complex I inhibited by rote , open3 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.88) |
| 6ZKN | Complex I inhibited by rotenone, OPEN3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKO | Native complex I, closed | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKP | Native complex I, OPEN1 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKQ | Native complex I, OPEN2 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKR | Native complex I, open3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKR | Native complex I, OPEN3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKS | Deactive complex I, OPEN1 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKT | Deactive complex I, open2 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.89) |
| 6ZKT | Deactive complex I, OPEN2 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKU | Deactive complex I, open3 | electron microscopy | L | 3PE, PC1, CDL, MYR | 6 (best 0.88) |
| 6ZKU | Deactive complex I, OPEN3 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 6ZKV | Deactive complex I, open4 | electron microscopy | L | 3PE, PC1, CDL, MYR | 7 (best 0.88) |
| 6ZKV | Deactive complex I, OPEN4 | electron microscopy | L | 3PE, PC1, CDL, MYR | — |
| 7ZDM | Complex I from Ovis aries at pH5.5, Closed state | electron microscopy | L | 3PE, PC1, MYR | 7 (best 0.88) |
| 7ZDP | Complex I from Ovis aries at pH9, Open state | electron microscopy | L | MYR | — |
| O78756 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 5 (O78756) | predicted | A | — | 6 (best 0.57) |
Ligands
Experiment against prediction
- 6ZKV chain L against the predicted model O78756: TM-score 0.99, RMSD 0.75 Å
- 6ZKV chain L against the predicted model O78756: TM-score 0.99, RMSD 0.75 Å
- 6ZKU chain L against the predicted model O78756: TM-score 0.99, RMSD 0.75 Å
- 6ZKU chain L against the predicted model O78756: TM-score 0.99, RMSD 0.75 Å
- 6ZKN chain L against the predicted model O78756: TM-score 0.99, RMSD 0.76 Å
- 6ZKM chain L against the predicted model O78756: TM-score 0.99, RMSD 0.76 Å
- 6ZKN chain L against the predicted model O78756: TM-score 0.99, RMSD 0.76 Å
- 6ZKR chain L against the predicted model O78756: TM-score 0.98, RMSD 1.33 Å
- 6ZKR chain L against the predicted model O78756: TM-score 0.98, RMSD 1.33 Å
- 6ZKP chain L against the predicted model O78756: TM-score 0.98, RMSD 1.45 Å
Elsewhere
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