UniProt O78755
NADH-ubiquinone oxidoreductase chain 4 (O78755)
NADH-ubiquinone oxidoreductase chain 4 (UniProt O78755), EC 7.1.1.2: 30 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O78755
- Protein
- NADH-ubiquinone oxidoreductase chain 4
- EC
- 7.1.1.2
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 35 · 5 records with a druggable one
Structures
31 records of O78755 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LNK | Entire ovine respiratory complex I | electron microscopy | M | PC1, CDL, 3PE | — |
| 5LNK | Entire ovine respiratory complex I | electron microscopy | M | PC1, CDL, 3PE | — |
| 6ZKA | Membrane domain of open complex I during turnover | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | M | 3PE, PC1, CDL | 10 (best 0.88) |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKC | Complex I during turnover, closed | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKD | Complex I during turnover, OPEN1 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKE | Complex I during turnover, OPEN2 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKF | Complex I during turnover, open3 | electron microscopy | M | 3PE, PC1, CDL | 8 (best 0.89) |
| 6ZKF | Complex I during turnover, OPEN3 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKG | Complex I with NADH, closed | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKH | Complex I with NADH, open1 | electron microscopy | M | 3PE, PC1, CDL | 7 (best 0.88) |
| 6ZKH | Complex I with NADH, OPEN1 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKI | Complex I with NADH, OPEN2 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKJ | Complex I with NADH, OPEN3 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKK | Complex I inhibited by rotenone, closed | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKL | Complex I inhibited by rote , open1 | electron microscopy | M | 3PE, PC1, CDL | 7 (best 0.88) |
| 6ZKL | Complex I inhibited by rotenone, OPEN1 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKM | Complex I inhibited by rotenone, OPEN2 | electron microscopy | M | 3PE, PC1, CDL, 970 | — |
| 6ZKN | Complex I inhibited by rotenone, OPEN3 | electron microscopy | M | 3PE, PC1, CDL, 970 | — |
| 6ZKO | Native complex I, closed | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKP | Native complex I, OPEN1 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKQ | Native complex I, OPEN2 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKR | Native complex I, open3 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKR | Native complex I, OPEN3 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKS | Deactive complex I, OPEN1 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKT | Deactive complex I, OPEN2 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKU | Deactive complex I, OPEN3 | electron microscopy | M | 3PE, PC1, CDL | — |
| 6ZKV | Deactive complex I, OPEN4 | electron microscopy | M | 3PE, PC1, CDL | — |
| 7ZDP | Complex I from Ovis aries at pH9, Open state | electron microscopy | M | — | — |
| O78755 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (O78755) | predicted | A | — | 3 (best 0.61) |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 29 records
- CDL · Cardiolipin · in 29 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 29 records
- 970 · (2r,6as,12as)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12, 12A-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6ah)-one · in 2 records
Experiment against prediction
- 6ZKP chain M against the predicted model O78755: TM-score 0.99, RMSD 0.89 Å
- 6ZKJ chain M against the predicted model O78755: TM-score 0.99, RMSD 0.90 Å
- 6ZKQ chain M against the predicted model O78755: TM-score 0.99, RMSD 0.90 Å
- 6ZKF chain M against the predicted model O78755: TM-score 0.99, RMSD 0.90 Å
- 6ZKF chain M against the predicted model O78755: TM-score 0.99, RMSD 0.90 Å
- 6ZKT chain M against the predicted model O78755: TM-score 0.99, RMSD 0.90 Å
- 6ZKO chain M against the predicted model O78755: TM-score 0.99, RMSD 0.91 Å
- 6ZKI chain M against the predicted model O78755: TM-score 0.99, RMSD 0.91 Å
- 6ZKD chain M against the predicted model O78755: TM-score 0.99, RMSD 0.91 Å
- 6ZKB chain M against the predicted model O78755: TM-score 0.99, RMSD 0.92 Å
Elsewhere
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