UniProt O78753
NADH-ubiquinone oxidoreductase chain 3 (O78753)
NADH-ubiquinone oxidoreductase chain 3 (UniProt O78753), EC 7.1.1.2: 31 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O78753
- Protein
- NADH-ubiquinone oxidoreductase chain 3
- EC
- 7.1.1.2
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 15 · 5 records with a druggable one
Structures
32 records of O78753 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LNK | Entire ovine respiratory complex I | electron microscopy | A | PC1, CDL, 3PE | — |
| 5LNK | Entire ovine respiratory complex I | electron microscopy | A | PC1, CDL, 3PE | — |
| 6ZKA | Membrane domain of open complex I during turnover | electron microscopy | A | PC1, 3PE | — |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | A | 3PE | 1 (best 0.90) |
| 6ZKB | Membrane domain of closed complex I during turnover | electron microscopy | A | 3PE | — |
| 6ZKC | Complex I during turnover, closed | electron microscopy | A | PC1, 3PE | — |
| 6ZKD | Complex I during turnover, OPEN1 | electron microscopy | A | PC1, 3PE, DCQ | — |
| 6ZKE | Complex I during turnover, OPEN2 | electron microscopy | A | PC1, 3PE, DCQ | — |
| 6ZKF | Complex I during turnover, open3 | electron microscopy | A | PC1, 3PE | 3 (best 0.90) |
| 6ZKF | Complex I during turnover, OPEN3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKG | Complex I with NADH, closed | electron microscopy | A | PC1, 3PE | — |
| 6ZKH | Complex I with NADH, open1 | electron microscopy | A | PC1, 3PE | 4 (best 0.90) |
| 6ZKH | Complex I with NADH, OPEN1 | electron microscopy | A | PC1, 3PE | — |
| 6ZKI | Complex I with NADH, OPEN2 | electron microscopy | A | PC1, 3PE | — |
| 6ZKJ | Complex I with NADH, OPEN3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKK | Complex I inhibited by rotenone, closed | electron microscopy | A | PC1, 3PE | — |
| 6ZKL | Complex I inhibited by rote , open1 | electron microscopy | A | PC1, 3PE | 3 (best 0.90) |
| 6ZKL | Complex I inhibited by rotenone, OPEN1 | electron microscopy | A | PC1, 3PE | — |
| 6ZKM | Complex I inhibited by rotenone, OPEN2 | electron microscopy | A | PC1, 3PE | — |
| 6ZKN | Complex I inhibited by rotenone, OPEN3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKO | Native complex I, closed | electron microscopy | A | PC1, 3PE | — |
| 6ZKP | Native complex I, OPEN1 | electron microscopy | A | PC1, 3PE | — |
| 6ZKQ | Native complex I, OPEN2 | electron microscopy | A | PC1, 3PE | — |
| 6ZKR | Native complex I, open3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKR | Native complex I, OPEN3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKS | Deactive complex I, OPEN1 | electron microscopy | A | PC1, 3PE | — |
| 6ZKT | Deactive complex I, OPEN2 | electron microscopy | A | PC1, 3PE | — |
| 6ZKU | Deactive complex I, open3 | electron microscopy | A | PC1, 3PE | 4 (best 0.88) |
| 6ZKU | Deactive complex I, OPEN3 | electron microscopy | A | PC1, 3PE | — |
| 6ZKV | Deactive complex I, OPEN4 | electron microscopy | A | PC1, 3PE | — |
| 7ZDP | Complex I from Ovis aries at pH9, Open state | electron microscopy | A | — | — |
| O78753 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 3 (O78753) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6ZKB chain A against the predicted model O78753: TM-score 0.92, RMSD 1.23 Å
- 6ZKB chain A against the predicted model O78753: TM-score 0.92, RMSD 1.23 Å
- 6ZKG chain A against the predicted model O78753: TM-score 0.92, RMSD 1.25 Å
- 6ZKO chain A against the predicted model O78753: TM-score 0.92, RMSD 1.26 Å
- 6ZKC chain A against the predicted model O78753: TM-score 0.92, RMSD 1.26 Å
- 6ZKK chain A against the predicted model O78753: TM-score 0.92, RMSD 1.32 Å
- 6ZKA chain A against the predicted model O78753: TM-score 0.81, RMSD 2.20 Å
- 6ZKL chain A against the predicted model O78753: TM-score 0.79, RMSD 2.44 Å
- 6ZKL chain A against the predicted model O78753: TM-score 0.79, RMSD 2.44 Å
- 6ZKM chain A against the predicted model O78753: TM-score 0.79, RMSD 2.29 Å
Elsewhere
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