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Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the post-gap state

Analyse Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the post-gap… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6WJ3
Type
protein
Length
1,168 residues
Chains
8
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q6IAA8, Q9Y2Q5, Q9UHA4, Q0VGL1, A0A0C4DGV4, Q7L523, Q9HB90, Q8NBW4
Ligands
GDP, U3J

Structure

electron microscopy · 8 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein96—Q6IAA8
B—protein120—Q9Y2Q5
C—protein119—Q9UHA4
D—protein94—Q0VGL1
E—protein91—A0A0C4DGV4
F—protein281—Q7L523
G—protein308—Q9HB90
H—protein59—Q8NBW4

Ligands and binding sites

  • GDP · Guanosine-5'-diphosphate · ligand · chains F, H
  • U3J · xanthosine diphosphate · ligand · chains G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6WJ3 · CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state · the same entry in another collection · chain H against H, TM-score 1.00
  • Q9HB90 · AlphaFold monomer V2.0 prediction for RAS-related GTP-binding protein C (Q9HB90) · a predicted model of the same protein · chain G against A, TM-score 0.97
  • Q9UHA4 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR3 (Q9UHA4) · a predicted model of the same protein · chain C against A, TM-score 0.94
  • Q9Y2Q5 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR2 (Q9Y2Q5) · a predicted model of the same protein · chain B against A, TM-score 0.93
  • Q0VGL1 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR4 (Q0VGL1) · a predicted model of the same protein · chain D against A, TM-score 0.88

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