UniProt Q9HB90
Ras-related GTP-binding protein C (Q9HB90)
Ras-related GTP-binding protein C (UniProt Q9HB90), EC 3.6.5.-: 22 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9HB90
- Protein
- Ras-related GTP-binding protein C
- EC
- 3.6.5.-
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 34 · 6 records with a druggable one
Structures
23 records of Q9HB90 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LLU | Crystal structure of the nucleotide-binding domain of Ras-related GTP-binding protein C | x-ray diffraction | A | — | — |
| 3LLU | Crystal structure of the nucleotide-binding domain of RAS-related GTP- binding protein C | x-ray diffraction | A | — | — |
| 6CES | Cryo-EM structure of GATOR1-RAG | electron microscopy | C | — | — |
| 6CES | Cryo-EM structure of GATOR1-rag | electron microscopy | C | — | — |
| 6EHR | The crystal structure of the human lamtor-raga ctd-ragc ctd complex | x-ray diffraction | G | — | — |
| 6NZD | Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator) | electron microscopy | G | L8S | — |
| 6S6A | Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex | x-ray diffraction | C, D | 9JE, GDP | 13 (best 0.77) |
| 6S6A | Crystal structure of raga-Q66L/RAGC-T90N GTPase heterodimer complex | x-ray diffraction | C, D | 9JE, GDP | — |
| 6S6D | Crystal structure of raga-Q66L-GTP/RAGC-S75N-GDP GTPase heterodimer complex | x-ray diffraction | C, D | GDP, 9JE | — |
| 6SB0 | Cryo-EM structure of MTORC1 bound to PRAS40-fused active RAGA/C gtpases | electron microscopy | D, J | GDP | — |
| 6SB2 | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | electron microscopy | D, J | GDP | 4 (best 0.82) |
| 6SB2 | Cryo-EM structure of MTORC1 bound to active RAGA/C gtpases | electron microscopy | D, J | GDP | — |
| 6U62 | Raptor-rag-ragulator complex | electron microscopy | C | GDP | — |
| 6ULG | Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex | electron microscopy | G | GNP, MG | — |
| 6WJ2 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state | electron microscopy | G | L8S, MG | 5 (best 0.79) |
| 6WJ2 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the pre-gap state | electron microscopy | G | L8S, MG | — |
| 6WJ3 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state | electron microscopy | G | U3J | 4 (best 0.80) |
| 6WJ3 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the post-gap state | electron microscopy | G | U3J | — |
| 7T3A | GATOR1-rag-ragulator - inhibitory complex | electron microscopy | L | — | — |
| 7T3B | GATOR1-RAG-RAGULATOR - GAP Complex | electron microscopy | E | GDP, AF3 | 5 (best 0.74) |
| 7T3B | GATOR1-rag-ragulator - gap complex | electron microscopy | E | GDP, AF3 | — |
| 7T3C | GATOR1-rag-ragulator - dual complex | electron microscopy | E, L | GDP, AF3 | — |
| Q9HB90 | AlphaFold monomer V2.0 prediction for RAS-related GTP-binding protein C (Q9HB90) | predicted | A | — | 3 (best 0.51) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 10 records
- 9JE · pentane-1,5-diol · in 3 records
- AF3 · Aluminum fluoride · in 3 records
- L8S · 9-{5-O-[(S)-hydroxy{[(r)-hydroxy(thiophosphonooxy) phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione · in 3 records
- MG · Magnesium ion · in 3 records
- U3J · xanthosine diphosphate · in 2 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 1 record
Experiment against prediction
- 6WJ3 chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.18 Å
- 6WJ3 chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.18 Å
- 6ULG chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.22 Å
- 6NZD chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.23 Å
- 6WJ2 chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.28 Å
- 6WJ2 chain G against the predicted model Q9HB90: TM-score 0.97, RMSD 1.28 Å
- 7T3B chain E against the predicted model Q9HB90: TM-score 0.96, RMSD 1.39 Å
- 7T3B chain E against the predicted model Q9HB90: TM-score 0.96, RMSD 1.39 Å
- 6EHR chain G against the predicted model Q9HB90: TM-score 0.96, RMSD 1.13 Å
- 3LLU chain A against the predicted model Q9HB90: TM-score 0.95, RMSD 1.27 Å
Elsewhere
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