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Ligand · L8S

L8S · 9-{5-O-[(S)-hydroxy{[(r)-hydroxy(thiophosphonooxy) phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione

L8S, 9-{5-O-[(S)-hydroxy{[(r)-hydroxy(thiophosphonooxy) phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione (C10 H15 N4 O14 P3 S, 540.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2…

Component
L8S
Formula
C10 H15 N4 O14 P3 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

L8S in 2 structures; the first of them:

  • 6NZD · Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator) · L8S G500 · binds ARG70, ARG71, SER72, GLY73, LYS74, SER75, SER76, THR90 and 11 more
  • 6WJ2 · Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the pre-gap state · L8S G500 · binds ARG71, SER72, GLY73, LYS74, SER75, SER76, THR90, LEU91 and 8 more

Residues it binds most

SER 2, GLY 2, LYS 2, THR 2, ARG 2, LEU 2, ASN 2, HIS 2, ILE 2, PHE 1 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion

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