UniProt Q6IAA8
Ragulator complex protein LAMTOR1 (Q6IAA8)
Ragulator complex protein LAMTOR1 (UniProt Q6IAA8): 35 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6IAA8
- Protein
- Ragulator complex protein LAMTOR1
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 67 · 17 records with a druggable one
Structures
36 records of Q6IAA8 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5X6U | Crystal structure of human heteropentameric complex | x-ray diffraction | E | — | 4 (best 0.56) |
| 5X6U | Crystal structure of human heteropentameric complex | x-ray diffraction | E | — | — |
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | E | — | 5 (best 0.70) |
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | E | — | — |
| 5Y39 | Crystal structure of Ragulator complex (p18 76-145) | x-ray diffraction | A, F | — | — |
| 5Y39 | Crystal structure of ragulator complex (P18 76-145) | x-ray diffraction | A, F | — | — |
| 5Y3A | Crystal structure of Ragulator complex (p18 49-161) | x-ray diffraction | A, F | SO4 | 7 (best 0.71) |
| 5Y3A | Crystal structure of ragulator complex (P18 49-161) | x-ray diffraction | A, F | SO4 | — |
| 5YK3 | human Ragulator complex | x-ray diffraction | k, A, F | — | — |
| 5YK3 | Human ragulator complex | x-ray diffraction | k, A, F | — | — |
| 6B9X | Crystal structure of Ragulator | x-ray diffraction | A | — | 4 (best 0.67) |
| 6B9X | Crystal structure of ragulator | x-ray diffraction | A | — | — |
| 6EHP | The crystal structure of the human LAMTOR complex | x-ray diffraction | E | CL | 3 (best 0.68) |
| 6EHP | The crystal structure of the human lamtor complex | x-ray diffraction | E | CL | — |
| 6EHR | The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex | x-ray diffraction | E | — | 7 (best 0.72) |
| 6EHR | The crystal structure of the human lamtor-raga ctd-ragc ctd complex | x-ray diffraction | E | — | — |
| 6NZD | Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | electron microscopy | A | — | 4 (best 0.66) |
| 6NZD | Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator) | electron microscopy | A | — | — |
| 6U62 | Raptor-Rag-Ragulator complex | electron microscopy | D | — | 4 (best 0.77) |
| 6U62 | Raptor-rag-ragulator complex | electron microscopy | D | — | — |
| 6ULG | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | electron microscopy | E | — | 1 (best 0.68) |
| 6ULG | Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex | electron microscopy | E | — | — |
| 6WJ2 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state | electron microscopy | A | — | 7 (best 0.77) |
| 6WJ2 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the pre-gap state | electron microscopy | A | — | — |
| 6WJ3 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state | electron microscopy | A | — | 4 (best 0.63) |
| 6WJ3 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the post-gap state | electron microscopy | A | — | — |
| 7T3A | GATOR1-RAG-RAGULATOR - Inhibitory Complex | electron microscopy | M | — | 2 (best 0.74) |
| 7T3A | GATOR1-rag-ragulator - inhibitory complex | electron microscopy | M | — | — |
| 7T3B | GATOR1-RAG-RAGULATOR - GAP Complex | electron microscopy | F | — | 3 (best 0.65) |
| 7T3B | GATOR1-rag-ragulator - gap complex | electron microscopy | F | — | — |
| 7T3C | GATOR1-RAG-RAGULATOR - Dual Complex | electron microscopy | F, M | — | 2 (best 0.76) |
| 7T3C | GATOR1-rag-ragulator - dual complex | electron microscopy | F, M | — | — |
| 7UXC | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion | electron microscopy | F, M | — | 5 (best 0.80) |
| 7UXH | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | electron microscopy | H, O, X, e | — | 2 (best 0.79) |
| 8DHB | Active FLCN GAP complex | electron microscopy | C | — | 3 (best 0.80) |
| Q6IAA8 | AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR1 (Q6IAA8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5Y39 chain F against the predicted model Q6IAA8: TM-score 0.88, RMSD 0.66 Å
- 5Y39 chain F against the predicted model Q6IAA8: TM-score 0.88, RMSD 0.66 Å
- 5Y3A chain A against the predicted model Q6IAA8: TM-score 0.87, RMSD 1.53 Å
- 5Y3A chain A against the predicted model Q6IAA8: TM-score 0.87, RMSD 1.53 Å
- 5YK3 chain k against the predicted model Q6IAA8: TM-score 0.86, RMSD 1.64 Å
- 5YK3 chain k against the predicted model Q6IAA8: TM-score 0.86, RMSD 1.64 Å
- 5Y3A chain F against the predicted model Q6IAA8: TM-score 0.86, RMSD 1.28 Å
- 5Y3A chain F against the predicted model Q6IAA8: TM-score 0.86, RMSD 1.28 Å
- 5Y39 chain A against the predicted model Q6IAA8: TM-score 0.85, RMSD 1.37 Å
- 5Y39 chain A against the predicted model Q6IAA8: TM-score 0.85, RMSD 1.37 Å
Elsewhere
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