UniProt Q7L523
Ras-related GTP-binding protein A (Q7L523)
Ras-related GTP-binding protein A (UniProt Q7L523), EC 3.6.5.-: 32 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 129 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q7L523
- Protein
- Ras-related GTP-binding protein A
- EC
- 3.6.5.-
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 129 · 19 records with a druggable one
Structures
33 records of Q7L523 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | F | — | 2 (best 0.75) |
| 5X6V | Crystal structure of human heteroheptameric complex | x-ray diffraction | F | — | 2 (best 0.75) |
| 6CES | Cryo-EM structure of GATOR1-RAG | electron microscopy | A | GNP | 4 (best 0.80) |
| 6CES | Cryo-EM structure of GATOR1-rag | electron microscopy | A | GNP | 4 (best 0.80) |
| 6EHR | The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex | x-ray diffraction | F | — | 5 (best 0.71) |
| 6EHR | The crystal structure of the human lamtor-raga ctd-ragc ctd complex | x-ray diffraction | F | — | — |
| 6NZD | Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | electron microscopy | F | GDP | 7 (best 0.78) |
| 6NZD | Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator) | electron microscopy | F | GDP | — |
| 6S6A | Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex | x-ray diffraction | A, B | GTP, MG, 9JE | 17 (best 0.77) |
| 6S6A | Crystal structure of raga-Q66L/RAGC-T90N GTPase heterodimer complex | x-ray diffraction | A, B | GTP, MG, 9JE | — |
| 6S6D | Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex | x-ray diffraction | A, B | GTP, MG, 9JE | 16 (best 0.77) |
| 6S6D | Crystal structure of raga-Q66L-GTP/RAGC-S75N-GDP GTPase heterodimer complex | x-ray diffraction | A, B | GTP, MG, 9JE | — |
| 6SB0 | Cryo-EM structure of MTORC1 bound to PRAS40-fused active RAGA/C gtpases | electron microscopy | C, I | GTP | — |
| 6SB2 | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | electron microscopy | C, I | GTP | 5 (best 0.86) |
| 6SB2 | Cryo-EM structure of MTORC1 bound to active RAGA/C gtpases | electron microscopy | C, I | GTP | — |
| 6U62 | Raptor-Rag-Ragulator complex | electron microscopy | B | GTP, MG | 7 (best 0.77) |
| 6U62 | Raptor-rag-ragulator complex | electron microscopy | B | GTP, MG | — |
| 6ULG | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | electron microscopy | F | GDP | 6 (best 0.80) |
| 6ULG | Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex | electron microscopy | F | GDP | — |
| 6WJ2 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state | electron microscopy | F | GDP | 7 (best 0.79) |
| 6WJ2 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the pre-gap state | electron microscopy | F | GDP | — |
| 6WJ3 | CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state | electron microscopy | F | GDP | 8 (best 0.80) |
| 6WJ3 | Cryoem structure of the SLC38A9-raga-ragc-ragulator complex in the post-gap state | electron microscopy | F | GDP | — |
| 7T3A | GATOR1-RAG-RAGULATOR - Inhibitory Complex | electron microscopy | K | GNP | 4 (best 0.78) |
| 7T3A | GATOR1-rag-ragulator - inhibitory complex | electron microscopy | K | GNP | — |
| 7T3B | GATOR1-RAG-RAGULATOR - GAP Complex | electron microscopy | D | GDP, AF3 | 4 (best 0.75) |
| 7T3B | GATOR1-rag-ragulator - gap complex | electron microscopy | D | GDP, AF3 | — |
| 7T3C | GATOR1-RAG-RAGULATOR - Dual Complex | electron microscopy | D, K | GDP, AF3 | 9 (best 0.77) |
| 7T3C | GATOR1-rag-ragulator - dual complex | electron microscopy | D, K | GDP, AF3 | — |
| 7UXC | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion | electron microscopy | D, K | GTP, MG | 6 (best 0.82) |
| 7UXH | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | electron microscopy | F, M, V, c | GTP, MG | 5 (best 0.83) |
| 8DHB | Active FLCN GAP complex | electron microscopy | B | GDP | 8 (best 0.80) |
| Q7L523 | AlphaFold monomer V2.0 prediction for RAS-related GTP-binding protein a (Q7L523) | predicted | A | — | 3 (best 0.45) |
Ligands
Experiment against prediction
- 7UXH chain F against the predicted model Q7L523: TM-score 0.98, RMSD 0.79 Å
- 7UXC chain D against the predicted model Q7L523: TM-score 0.98, RMSD 0.82 Å
- 6S6A chain B against the predicted model Q7L523: TM-score 0.98, RMSD 0.85 Å
- 6S6A chain B against the predicted model Q7L523: TM-score 0.98, RMSD 0.85 Å
- 6S6A chain A against the predicted model Q7L523: TM-score 0.98, RMSD 0.87 Å
- 6S6A chain A against the predicted model Q7L523: TM-score 0.98, RMSD 0.87 Å
- 6U62 chain B against the predicted model Q7L523: TM-score 0.98, RMSD 0.91 Å
- 6U62 chain B against the predicted model Q7L523: TM-score 0.98, RMSD 0.91 Å
- 6S6D chain A against the predicted model Q7L523: TM-score 0.98, RMSD 0.99 Å
- 6S6D chain A against the predicted model Q7L523: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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