Research workbench
Human tfiid lobe a canonical
Analyse Human tfiid lobe a canonical in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MZD
- Type
- protein
- Length
- 1,481 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 1; Transcription initiation factor tfiid…
- EC
- 2.3.1.48, 2.7.11.1
- UniProt
- P21675, Q5VWG9, O00268, Q15542, P49848, Q16594, Q12962, Q15544, Q16514, Q15543, P20226
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 12 distinct chains · 43% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1) | protein | 71 | 31% helix, 4% strand | P21675 |
| C | Transcription initiation factor tfiid subunit 3 | protein | 93 | 68% helix, 2% strand | Q5VWG9 |
| D | Transcription initiation factor tfiid subunit 4 | protein | 102 | 72% helix, 1% strand | O00268 |
| F | Transcription initiation factor tfiid subunit 5 | protein | 473 | 20% helix, 27% strand | Q15542 |
| H | Transcription initiation factor tfiid subunit 6 | protein | 72 | 60% helix, 0% strand | P49848 |
| L | Transcription initiation factor tfiid subunit 9 | protein | 104 | 65% helix, 0% strand | Q16594 |
| N | Transcription initiation factor tfiid subunit 10 | protein | 82 | 60% helix, 2% strand | Q12962 |
| P | Transcription initiation factor tfiid subunit 11 | protein | 89 | 69% helix, 0% strand | Q15544 |
| Q | Transcription initiation factor tfiid subunit 12 | protein | 74 | 66% helix, 1% strand | Q16514 |
| S | Transcription initiation factor tfiid subunit 13 | protein | 45 | 67% helix, 0% strand | Q15543 |
| T | Tata-box-binding protein | protein | 180 | 27% helix, 40% strand | P20226 |
| Y | POLY(UNK) | protein | 96 | 32% helix, 1% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1012 | 0.87 | 0.88 | 106 | empty |
| 2 | 763 | 0.82 | 0.85 | 96 | empty |
| 3 | 645 | 0.80 | 0.85 | 60 | empty |
| 4 | 100 | 0.75 | 0.95 | 26 | empty |
| 5 | 52 | 0.69 | 0.97 | 18 | empty |
Interfaces
28 interfaces between chains.
- C–N · 2364 Ų buried · 18 hydrogen bonds · protein-protein
- A–T · 2139 Ų buried · 23 hydrogen bonds · protein-protein
- H–L · 1700 Ų buried · 4 hydrogen bonds · protein-protein
- D–Q · 1647 Ų buried · 7 hydrogen bonds · protein-protein
- P–S · 1623 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6MZD · Human TFIID Lobe A canonical · the same entry in another collection · chain Y against Y, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21675
- Every structure of UniProt Q5VWG9
- Every structure of UniProt O00268
- Every structure of UniProt Q15542
- Every structure of UniProt P49848
- Every structure of UniProt Q16594
- Every structure of UniProt Q12962
- Every structure of UniProt Q15544
- Every structure of UniProt Q16514
- Every structure of UniProt Q15543
- Every structure of UniProt P20226
- Elsewhere: RCSB PDB 6MZD · PDBe 6MZD · UniProt P21675 · UniProt Q5VWG9 · UniProt O00268 · UniProt Q15542 · UniProt P49848 · UniProt Q16594 · UniProt Q12962 · UniProt Q15544 · UniProt Q16514 · UniProt Q15543 · UniProt P20226
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