Research workbench
Bovine heart cytochrome C oxidase in catalitic intermediates at 1.80 ångström resolution
Analyse Bovine heart cytochrome C oxidase in catalitic intermediates at 1.80 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JUW
- Type
- protein
- Length
- 3,558 residues
- Chains
- 26
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.8
- Source
- Bos taurus
- Molecule
- Cytochrome c oxidase subunit 1; Cytochrome c oxidase subunit 2; Cytochrome c oxidase…
- EC
- 1.9.3.1
- UniProt
- P00396, P68530, P00415, P00423, P00426, P00428, P07471, P00429, P04038, P07470, P13183, P00430, P10175
- Ligands
- CHD, PGV, TGL, PEK, HEA, CDL, PSC, CUA, NA, CU, MG, ZN, PO4
- Pockets
- 20 · best druggability 0.91
Structure
x-ray diffraction · resolution 1.8 · 13 distinct chains · 59% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, N | Cytochrome c oxidase subunit 1 (EC 1.9.3.1) | protein | 514 | 72% helix, 1% strand | P00396 |
| B, O | Cytochrome c oxidase subunit 2 | protein | 227 | 35% helix, 26% strand | P68530 |
| C, P | Cytochrome c oxidase subunit 3 | protein | 259 | 76% helix, 0% strand | P00415 |
| D, Q | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | protein | 144 | 52% helix, 3% strand | P00423 |
| E, R | Cytochrome c oxidase subunit 5A, mitochondrial | protein | 105 | 64% helix, 1% strand | P00426 |
| F, S | Cytochrome c oxidase subunit 5B | protein | 98 | 15% helix, 27% strand | P00428 |
| G, T | Cytochrome c oxidase subunit 6A2, mitochondrial | protein | 84 | 30% helix, 2% strand | P07471 |
| H, U | Cytochrome c oxidase subunit 6B1 | protein | 79 | 59% helix, 1% strand | P00429 |
| I, V | Cytochrome c oxidase subunit 6C | protein | 73 | 70% helix, 1% strand | P04038 |
| J, W | Cytochrome c oxidase subunit 7A1, mitochondrial | protein | 58 | 67% helix, 0% strand | P07470 |
| K, X | Cytochrome c oxidase subunit 7B, mitochondrial | protein | 49 | 49% helix, 0% strand | P13183 |
| L, Y | Cytochrome c oxidase subunit 7C, mitochondrial | protein | 46 | 63% helix, 0% strand | P00430 |
| M, Z | Cytochrome c oxidase subunit 8B, mitochondrial | protein | 43 | 67% helix, 2% strand | P10175 |
Ligands and binding sites
- CHD · Cholic acid · ligand · 9 copies · chains A, C, P, J, G, N, O, L, M, W, B, T, Y, Z
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · ligand · 8 copies · chains A, D, K, M, C, F, N, Q, X, Z, P, S, G, U, H, T
- TGL · Tristearoylglycerol · ligand · 6 copies · chains A, B, I, D, L, N, O, V, Q, Y
- PEK · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5E,8E,11E,14E)-icosa-5,8, 11,14-tetraenoate · ligand · 6 copies · chains A, C, T, G, F, N, O, P, B, S
- HEA · Heme-A · ligand · 4 copies · chains A, B, N, O
- CDL · Cardiolipin · ligand · 4 copies · chains C, J, G, N, O, P, W, A, B, T
- PSC · (7R,17E,20E)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide · ligand · 2 copies · chains A, B, E, I, N, O, R, V
- CUA · Dinuclear copper ion · ligand · 2 copies · chains B, O
- NA · Sodium ion · metal · 4 copies · chains A, C, N, P
- CU · Copper (II) ion · metal · 2 copies · chains A, N
- MG · Magnesium ion · metal · 2 copies · chains A, B, N, O
- ZN · Zinc ion · metal · 2 copies · chains F, S
- PO4 · Phosphate ion · ion · 2 copies · chains H, U
- EDO · 1,2-ethanediol · additive · 80 copies · chains A, L, M, B, D, F, H, C, J, G, E, K, N, Z, O, S, Y, Q, P, U, T, W, R
- DMU · Decyl-beta-D-maltopyranoside · additive · 25 copies · chains A, D, K, B, C, J, G, L, M, O, P, T, W, Q, X, N, Y, Z
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1060 | 0.91 | 0.93 | 121 | HEA |
| 2 | 1181 | 0.91 | 0.93 | 135 | HEA |
| 3 | 1074 | 0.86 | 0.87 | 84 | PGV |
| 4 | 1182 | 0.86 | 0.86 | 106 | PGV, PEK |
| 5 | 1019 | 0.84 | 0.85 | 93 | EDO |
Interfaces
80 interfaces between chains.
- A–B · 3633 Ų buried · 37 hydrogen bonds · protein-protein
- N–O · 3613 Ų buried · 39 hydrogen bonds · protein-protein
- N–P · 2652 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 2646 Ų buried · 19 hydrogen bonds · protein-protein
- A–L · 1767 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified, 5 covalent, 4 disulfide (covalent ligand, disulfide, formylation, acetylation, phosphorylation).
Compared structures
- 6JUW · Bovine heart cytochrome C oxidase in catalitic intermediates at 1.80 ångström resolution · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00396
- Every structure of UniProt P68530
- Every structure of UniProt P00415
- Every structure of UniProt P00423
- Every structure of UniProt P00426
- Every structure of UniProt P00428
- Every structure of UniProt P07471
- Every structure of UniProt P00429
- Every structure of UniProt P04038
- Every structure of UniProt P07470
- Every structure of UniProt P13183
- Every structure of UniProt P00430
- Every structure of UniProt P10175
- Elsewhere: RCSB PDB 6JUW · PDBe 6JUW · UniProt P00396 · UniProt P68530 · UniProt P00415 · UniProt P00423 · UniProt P00426 · UniProt P00428 · UniProt P07471 · UniProt P00429 · UniProt P04038 · UniProt P07470 · UniProt P13183 · UniProt P00430 · UniProt P10175
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.