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Ligand · HEA

HEA · Heme-A

HEA, Heme-A (C49 H56 Fe N4 O6, 852.9 g/mol), in the MolNFT structures on GenesisL1: bound in 83 records (67 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
HEA
Formula
C49 H56 Fe N4 O6
Class
ligand
Structures
83
PDB entries
67

Binding sites

HEA in 83 structures; the first of them:

  • 5J4Z · Architecture of tight respirasome · HEA BN602 · binds GLY27, ALA62, MET65, GLY125, TRP126, THR127, LEU381, SER382 and 4 more
  • 5J7Y · Architecture of loose respirasome · HEA BN602 · binds GLY27, ALA62, MET65, GLY125, TRP126, THR127, LEU381, SER382 and 4 more
  • 5LUF · Cryo-EM of bovine respirasome · HEA x603 · binds ALA24, GLY27, MET28, THR31, SER34, ILE37, ARG38, TYR54 and 26 more
  • 5X1F · CO bound cytochrome c oxidase without pump laser irradiation at 278K · HEA A601 · binds MET28, THR31, SER34, ILE37, ARG38, TYR54, VAL58, HIS61 and 20 more
  • 5Z62 · Structure of human cytochrome c oxidase · HEA A603 · binds ALA24, GLY27, THR31, SER34, ILE37, ARG38, TYR54, VAL58 and 26 more
  • 5Z85 · The structure of azide-bound cytochrome c oxidase determined using the another batch… · HEA A601 · binds LEU20, ALA24, GLY27, MET28, THR31, SER34, ILE37, ARG38 and 30 more
  • 5ZCQ · Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM… · HEA A601 · binds ALA24, GLY27, MET28, THR31, SER34, ILE37, ARG38, TYR54 and 29 more
  • 6HU9 · III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae · HEA a602 · binds PHE19, ILE23, GLY26, THR30, SER33, ILE36, ARG37, VAL59 and 25 more
  • 6JUW · Bovine heart cytochrome C oxidase in catalitic intermediates at 1.80 ångström resolution · HEA A601 · binds ALA24, GLY27, MET28, THR31, SER34, ILE37, ARG38, TYR54 and 28 more
  • 6JY3 · Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State · HEA A601 · binds ALA24, GLY27, MET28, THR31, SER34, ILE37, ARG38, TYR54 and 30 more
  • 6JY4 · Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State · HEA A601 · binds ALA24, GLY27, THR31, SER34, ILE37, ARG38, TYR54, VAL58 and 24 more
  • 6KOB · X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus… · HEA A1001 · binds LEU68, PHE69, GLY72, VAL73, LEU76, MET78, ARG79, TYR95 and 22 more
  • 6KOC · X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus… · HEA A1001 · binds LEU68, PHE69, GLY72, VAL73, LEU76, MET78, ARG79, TYR95 and 22 more

Residues it binds most

VAL 268, ILE 277, HIS 276, PHE 276, GLY 278, LEU 270, THR 267, MET 151, ARG 274, ALA 264 (residue and the binding sites it lines).

Found with

  • CU · Copper (II) ion
  • CUA · Dinuclear copper ion
  • MG · Magnesium ion
  • CDL · Cardiolipin
  • ZN · Zinc ion
  • NA · Sodium ion
  • PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate
  • PEK · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5E,8E,11E,14E)-icosa-5,8, 11,14-tetraenoate
  • CHD · Cholic acid
  • TGL · Tristearoylglycerol
  • DMU · Decyl-beta-D-maltopyranoside
  • PSC · (7R,17E,20E)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide

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