UniProt P68530
Cytochrome c oxidase subunit 2 (P68530)
Cytochrome c oxidase subunit 2 (UniProt P68530), EC 7.1.1.9: 122 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 181 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P68530
- Protein
- Cytochrome c oxidase subunit 2
- EC
- 7.1.1.9
- Experimental structures
- 122
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 181 · 22 records with a druggable one
Structures
123 records of P68530 in the MolNFT archive: 122 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OCC | Structure of bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | B, O | — | — |
| 1OCO | Bovine heart cytochrome C oxidase in carbon monoxide-bound state | x-ray diffraction | B, O | — | — |
| 1OCO | Bovine heart cytochrome C oxidase in carbon monoxide-bound state | x-ray diffraction | B, O | — | — |
| 1OCR | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 1OCR | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 1OCZ | Bovine heart cytochrome C oxidase in azide-bound state | x-ray diffraction | B, O | — | — |
| 1OCZ | Bovine heart cytochrome C oxidase in azide-bound state | x-ray diffraction | B, O | — | — |
| 1V54 | Bovine heart cytochrome c oxidase at the fully oxidized state | x-ray diffraction | B, O | — | — |
| 1V54 | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | B, O | — | — |
| 1V55 | Bovine heart cytochrome c oxidase at the fully reduced state | x-ray diffraction | B, O | — | — |
| 1V55 | Bovine heart cytochrome C oxidase at the fully reduced state | x-ray diffraction | B, O | — | — |
| 2DYR | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2DYR | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2DYS | Bovine heart cytochrome C oxidase modified by DCCD | x-ray diffraction | B, O | — | — |
| 2DYS | Bovine heart cytochrome C oxidase modified by dccd | x-ray diffraction | B, O | — | — |
| 2EIJ | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIJ | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIK | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIK | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIL | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2EIL | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2EIM | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIM | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | B, O | — | — |
| 2EIN | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2EIN | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | B, O | — | — |
| 2Y69 | Bovine heart cytochrome c oxidase re-refined with molecular oxygen | x-ray diffraction | B, O | — | — |
| 2Y69 | Bovine heart cytochrome C oxidase re-refined with molecular oxygen | x-ray diffraction | B, O | — | — |
| 2YBB | Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) | electron microscopy | M | — | — |
| 2YBB | Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (emd-1876) | electron microscopy | M | — | — |
| 2ZXW | Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 2ZXW | Bovine heart cytochrome C oxidase at the fully oxidized state (1-S X- ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 3ABK | Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) | x-ray diffraction | B, O | — | — |
| 3ABK | Bovine heart cytochrome C oxidase at the no-bound fully reduced state (50K) | x-ray diffraction | B, O | — | — |
| 3ABL | Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 3ABL | Bovine heart cytochrome C oxidase at the fully oxidized state (15-S X-ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 3ABM | Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 3ABM | Bovine heart cytochrome C oxidase at the fully oxidized state (200-S X-ray exposure dataset) | x-ray diffraction | B, O | — | — |
| 3AG1 | Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K | x-ray diffraction | B, O | — | — |
| 3AG1 | Bovine heart cytochrome C oxidase in the carbon monoxide-bound fully reduced state at 280 K | x-ray diffraction | B, O | — | — |
| 3AG2 | Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K | x-ray diffraction | B, O | — | — |
| 3AG2 | Bovine heart cytochrome C oxidase in the carbon monoxide-bound fully reduced state at 100 K | x-ray diffraction | B, O | — | — |
| 3AG3 | Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K | x-ray diffraction | B, O | — | — |
| 3AG3 | Bovine heart cytochrome C oxidase in the nitric oxide-bound fully reduced state at 100 K | x-ray diffraction | B, O | — | — |
| 3AG4 | Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K | x-ray diffraction | B, O | — | — |
| 3AG4 | Bovine heart cytochrome C oxidase in the cyanide ion-bound fully reduced state at 100 K | x-ray diffraction | B, O | — | — |
| 3ASN | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength | x-ray diffraction | B, O | — | — |
| 3ASN | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 ångström wavelength | x-ray diffraction | B, O | — | — |
| 3ASO | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength | x-ray diffraction | B, O | — | — |
| 3ASO | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 ångström wavelength | x-ray diffraction | B, O | — | — |
| 3WG7 | A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond… | x-ray diffraction | B, O | — | — |
| 3WG7 | A 1.9 ångström radiation damage free X-ray structure of large (420KDA) protein by femtosecond… | x-ray diffraction | B, O | — | — |
| 3X2Q | X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at… | x-ray diffraction | B, O | — | — |
| 3X2Q | X-ray structure of cyanide-bound bovine heart cytochrome C oxidase in the fully oxidized state at… | x-ray diffraction | B, O | — | — |
| 5B1A | Bovine heart cytochrome C oxidase in the fully oxidized state at 1.5 ångström resolution | x-ray diffraction | B, O | — | — |
| 5B1B | Bovine heart cytochrome C oxidase in the fully reduced state at 1.6 ångström resolution | x-ray diffraction | B, O | — | — |
| 5B3S | Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom… | x-ray diffraction | B, O | HEA, MG, TGL, CUA, PSC, PEK | 11 (best 0.91) |
| 5B3S | Bovine heart cytochrome C oxidase in the carbon monoxide-bound mixed- valence state at 1.68… | x-ray diffraction | B, O | — | — |
| 5GPN | Architecture of mammalian respirasome | electron microscopy | z | HEA, CU | 2 (best 0.82) |
| 5IY5 | Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution | x-ray diffraction | B, O | MG, HEA, TGL, CUA, PSC, CDL | 12 (best 0.91) |
| 5IY5 | Electron transfer complex of cytochrome C and cytochrome C oxidase at 2.0 ångström resolution | x-ray diffraction | B, O | — | — |
63 records more on the page itself.
Ligands
- HEA · Heme-A · in 65 records
- MG · Magnesium ion · in 64 records
- CDL · Cardiolipin · in 56 records
- CUA · Dinuclear copper ion · in 56 records
- CHD · Cholic acid · in 52 records
- PSC · (7R,17E,20E)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide · in 48 records
- TGL · Tristearoylglycerol · in 48 records
- PEK · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5E,8E,11E,14E)-icosa-5,8, 11,14-tetraenoate · in 44 records
- CU · Copper (II) ion · in 9 records
- CQX · (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl) oxane-3,4,5-triol · in 4 records
- LFA · Eicosane · in 4 records
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · in 1 record
- UNL · Unknown ligand · in 1 record
Experiment against prediction
- 5WAU chain b against the predicted model P68530: TM-score 0.98, RMSD 0.79 Å
- 5X19 chain O against the predicted model P68530: TM-score 0.98, RMSD 0.81 Å
- 5X1F chain O against the predicted model P68530: TM-score 0.98, RMSD 0.81 Å
- 5X1F chain O against the predicted model P68530: TM-score 0.98, RMSD 0.81 Å
- 5XDQ chain O against the predicted model P68530: TM-score 0.98, RMSD 0.82 Å
- 5XDQ chain O against the predicted model P68530: TM-score 0.98, RMSD 0.82 Å
- 5B3S chain O against the predicted model P68530: TM-score 0.98, RMSD 0.81 Å
- 5B3S chain O against the predicted model P68530: TM-score 0.98, RMSD 0.81 Å
- 7COH chain O against the predicted model P68530: TM-score 0.98, RMSD 0.82 Å
- 7COH chain O against the predicted model P68530: TM-score 0.98, RMSD 0.82 Å
Elsewhere
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