UniProt P00423
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (P00423)
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (UniProt P00423): 117 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00423
- Protein
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Experimental structures
- 117
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 52 · 12 records with a druggable one
Structures
118 records of P00423 in the MolNFT archive: 117 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OCC | Structure of bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 1OCO | Bovine heart cytochrome C oxidase in carbon monoxide-bound state | x-ray diffraction | D, Q | — | — |
| 1OCO | Bovine heart cytochrome C oxidase in carbon monoxide-bound state | x-ray diffraction | D, Q | — | — |
| 1OCR | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 1OCR | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 1OCZ | Bovine heart cytochrome C oxidase in azide-bound state | x-ray diffraction | D, Q | — | — |
| 1OCZ | Bovine heart cytochrome C oxidase in azide-bound state | x-ray diffraction | D, Q | — | — |
| 1V54 | Bovine heart cytochrome c oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 1V54 | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 1V55 | Bovine heart cytochrome c oxidase at the fully reduced state | x-ray diffraction | D, Q | — | — |
| 1V55 | Bovine heart cytochrome C oxidase at the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2DYR | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2DYR | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2DYS | Bovine heart cytochrome C oxidase modified by DCCD | x-ray diffraction | D, Q | — | — |
| 2DYS | Bovine heart cytochrome C oxidase modified by dccd | x-ray diffraction | D, Q | — | — |
| 2EIJ | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIJ | Bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIK | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIK | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIL | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2EIL | Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2EIM | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIM | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state | x-ray diffraction | D, Q | — | — |
| 2EIN | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2EIN | Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2OCC | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2OCC | Bovine heart cytochrome C oxidase at the fully oxidized state | x-ray diffraction | D, Q | — | — |
| 2Y69 | Bovine heart cytochrome c oxidase re-refined with molecular oxygen | x-ray diffraction | D, Q | — | — |
| 2Y69 | Bovine heart cytochrome C oxidase re-refined with molecular oxygen | x-ray diffraction | D, Q | — | — |
| 2YBB | Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) | electron microscopy | O | — | — |
| 2YBB | Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (emd-1876) | electron microscopy | O | — | — |
| 2ZXW | Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 2ZXW | Bovine heart cytochrome C oxidase at the fully oxidized state (1-S X- ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 3ABK | Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) | x-ray diffraction | D, Q | — | — |
| 3ABK | Bovine heart cytochrome C oxidase at the no-bound fully reduced state (50K) | x-ray diffraction | D, Q | — | — |
| 3ABL | Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 3ABL | Bovine heart cytochrome C oxidase at the fully oxidized state (15-S X-ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 3ABM | Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 3ABM | Bovine heart cytochrome C oxidase at the fully oxidized state (200-S X-ray exposure dataset) | x-ray diffraction | D, Q | — | — |
| 3AG1 | Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K | x-ray diffraction | D, Q | — | — |
| 3AG1 | Bovine heart cytochrome C oxidase in the carbon monoxide-bound fully reduced state at 280 K | x-ray diffraction | D, Q | — | — |
| 3AG2 | Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K | x-ray diffraction | D, Q | — | — |
| 3AG2 | Bovine heart cytochrome C oxidase in the carbon monoxide-bound fully reduced state at 100 K | x-ray diffraction | D, Q | — | — |
| 3AG3 | Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K | x-ray diffraction | D, Q | — | — |
| 3AG3 | Bovine heart cytochrome C oxidase in the nitric oxide-bound fully reduced state at 100 K | x-ray diffraction | D, Q | — | — |
| 3AG4 | Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K | x-ray diffraction | D, Q | — | — |
| 3AG4 | Bovine heart cytochrome C oxidase in the cyanide ion-bound fully reduced state at 100 K | x-ray diffraction | D, Q | — | — |
| 3ASN | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength | x-ray diffraction | D, Q | — | — |
| 3ASN | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 ångström wavelength | x-ray diffraction | D, Q | — | — |
| 3ASO | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength | x-ray diffraction | D, Q | — | — |
| 3ASO | Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 ångström wavelength | x-ray diffraction | D, Q | — | — |
| 3WG7 | A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond… | x-ray diffraction | D, Q | — | — |
| 3WG7 | A 1.9 ångström radiation damage free X-ray structure of large (420KDA) protein by femtosecond… | x-ray diffraction | D, Q | — | — |
| 3X2Q | X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at… | x-ray diffraction | D, Q | — | — |
| 3X2Q | X-ray structure of cyanide-bound bovine heart cytochrome C oxidase in the fully oxidized state at… | x-ray diffraction | D, Q | — | — |
| 5B1A | Bovine heart cytochrome C oxidase in the fully oxidized state at 1.5 ångström resolution | x-ray diffraction | D, Q | — | — |
| 5B1B | Bovine heart cytochrome C oxidase in the fully reduced state at 1.6 ångström resolution | x-ray diffraction | D, Q | — | — |
| 5B3S | Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom… | x-ray diffraction | D, Q | PGV, TGL | 5 (best 0.83) |
| 5B3S | Bovine heart cytochrome C oxidase in the carbon monoxide-bound mixed- valence state at 1.68… | x-ray diffraction | D, Q | — | — |
| 5IY5 | Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution | x-ray diffraction | D, Q | PGV, TGL, UNL | 3 (best 0.84) |
58 records more on the page itself.
Ligands
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · in 45 records
- TGL · Tristearoylglycerol · in 45 records
- CQX · (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl) oxane-3,4,5-triol · in 4 records
- UNL · Unknown ligand · in 1 record
Experiment against prediction
- 1OCR chain D against the predicted model P00423: TM-score 0.98, RMSD 0.62 Å
- 1OCR chain D against the predicted model P00423: TM-score 0.98, RMSD 0.62 Å
- 1OCR chain Q against the predicted model P00423: TM-score 0.98, RMSD 0.62 Å
- 1OCR chain Q against the predicted model P00423: TM-score 0.98, RMSD 0.62 Å
- 1OCO chain Q against the predicted model P00423: TM-score 0.98, RMSD 0.63 Å
- 1OCO chain Q against the predicted model P00423: TM-score 0.98, RMSD 0.63 Å
- 1OCO chain D against the predicted model P00423: TM-score 0.98, RMSD 0.63 Å
- 1OCO chain D against the predicted model P00423: TM-score 0.98, RMSD 0.63 Å
- 2OCC chain D against the predicted model P00423: TM-score 0.98, RMSD 0.64 Å
- 2OCC chain D against the predicted model P00423: TM-score 0.98, RMSD 0.64 Å
Elsewhere
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