UniProt Q9UGP5
DNA polymerase lambda (Q9UGP5)
DNA polymerase lambda (UniProt Q9UGP5), EC 2.7.7.7, 4.2.99.-: 149 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 73 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UGP5
- Protein
- DNA polymerase lambda
- EC
- 2.7.7.7, 4.2.99.-
- Experimental structures
- 149
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 73 · 17 records with a druggable one
Structures
150 records of Q9UGP5 in the MolNFT archive: 149 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NZP | Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda | solution nmr | A | — | — |
| 1NZP | Solution structure of the lyase domain of human DNA polymerase lambda | solution nmr | A | — | — |
| 1RZT | Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule | x-ray diffraction | A, E, I, M | — | — |
| 1RZT | Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule | x-ray diffraction | A, E, I, M | — | — |
| 1XSL | Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap | x-ray diffraction | A, E, I, M | — | — |
| 1XSL | Crystal structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap | x-ray diffraction | A, E, I, M | — | — |
| 1XSN | Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP | x-ray diffraction | A | — | — |
| 1XSN | Crystal structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddttp | x-ray diffraction | A | — | — |
| 1XSP | Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate | x-ray diffraction | A | — | — |
| 1XSP | Crystal structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate | x-ray diffraction | A | — | — |
| 2BCQ | DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dtmp | x-ray diffraction | A | — | — |
| 2BCQ | DNA polymerase lambda in complex with a DNA duplex containing an unpaired dtmp | x-ray diffraction | A | — | — |
| 2BCR | DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp | x-ray diffraction | A | — | — |
| 2BCR | DNA polymerase lambda in complex with a DNA duplex containing an unpaired damp | x-ray diffraction | A | — | — |
| 2BCS | DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dcmp | x-ray diffraction | A | — | — |
| 2BCS | DNA polymerase lambda in complex with a DNA duplex containing an unpaired dcmp | x-ray diffraction | A | — | — |
| 2BCU | DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp and a T:T mismatch | x-ray diffraction | A | — | — |
| 2BCU | DNA polymerase lambda in complex with a DNA duplex containing an unpaired damp and a T:T mismatch | x-ray diffraction | A | — | — |
| 2BCV | DNA polymerase lambda in complex with Dttp and a DNA duplex containing an unpaired Dtmp | x-ray diffraction | A | — | — |
| 2BCV | DNA polymerase lambda in complex with dttp and a DNA duplex containing an unpaired dtmp | x-ray diffraction | A | — | — |
| 2GWS | Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus | x-ray diffraction | A, E, I, M | — | — |
| 2GWS | Crystal structure of human DNA polymerase lambda with a G/G mismatch in the primer terminus | x-ray diffraction | A, E, I, M | — | — |
| 2JW5 | Polymerase Lambda BRCT domain | solution nmr | A | — | — |
| 2JW5 | Polymerase lambda brct domain | solution nmr | A | — | — |
| 2PFN | Na in the active site of DNA Polymerase lambda | x-ray diffraction | A | — | — |
| 2PFN | Na in the active site of DNA polymerase lambda | x-ray diffraction | A | — | — |
| 2PFO | DNA Polymerase lambda in complex with DNA and dUPNPP | x-ray diffraction | A | — | — |
| 2PFO | DNA polymerase lambda in complex with DNA and dupnpp | x-ray diffraction | A | — | — |
| 2PFP | DNA Polymerase lambda in complex with DNA and dCTP | x-ray diffraction | A | — | — |
| 2PFP | DNA polymerase lambda in complex with DNA and dctp | x-ray diffraction | A | — | — |
| 2PFQ | Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal | x-ray diffraction | A | — | — |
| 2PFQ | Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal | x-ray diffraction | A | — | — |
| 3C5F | Structure of a binary complex of the R517A Pol lambda mutant | x-ray diffraction | A, B | — | — |
| 3C5F | Structure of a binary complex of the R517A pol lambda mutant | x-ray diffraction | A, B | — | — |
| 3C5G | Structure of a ternary complex of the R517K Pol lambda mutant | x-ray diffraction | A, B | — | — |
| 3C5G | Structure of a ternary complex of the R517K pol lambda mutant | x-ray diffraction | A, B | — | — |
| 3HW8 | ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the… | x-ray diffraction | A | — | — |
| 3HW8 | Ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the… | x-ray diffraction | A | — | — |
| 3HWT | Ternary complex of DNA polymerase lambda bound to a two nucleotide gapped DNA substrate with a… | x-ray diffraction | A | — | — |
| 3HWT | Ternary complex of DNA polymerase lambda bound to a two nucleotide gapped DNA substrate with a… | x-ray diffraction | A | — | — |
| 3HX0 | ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA… | x-ray diffraction | A, F, K, P | — | — |
| 3HX0 | Ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA… | x-ray diffraction | A, F, K, P | — | — |
| 3MDA | DNA polymerase lambda in complex with araC | x-ray diffraction | A | — | — |
| 3MDA | DNA polymerase lambda in complex with arac | x-ray diffraction | A | — | — |
| 3MDC | DNA polymerase lambda in complex with dFdCTP | x-ray diffraction | A | — | — |
| 3MDC | DNA polymerase lambda in complex with dfdctp | x-ray diffraction | A | — | — |
| 3MGH | Binary complex of a DNA polymerase lambda loop mutant | x-ray diffraction | A, C | — | — |
| 3MGH | Binary complex of a DNA polymerase lambda loop mutant | x-ray diffraction | A, C | — | — |
| 3MGI | Ternary complex of a DNA polymerase lambda loop mutant | x-ray diffraction | A | — | — |
| 3MGI | Ternary complex of a DNA polymerase lambda loop mutant | x-ray diffraction | A | — | — |
| 3PML | crystal structure of a polymerase lambda variant with a dGTP analog opposite a templating T | x-ray diffraction | A, B | — | — |
| 3PML | Crystal structure of a polymerase lambda variant with a dgtp analog opposite a templating T | x-ray diffraction | A, B | — | — |
| 3PMN | ternary crystal structure of polymerase lambda variant with a GT mispair at the primer terminus… | x-ray diffraction | A | — | — |
| 3PMN | Ternary crystal structure of polymerase lambda variant with a gt mispair at the primer terminus… | x-ray diffraction | A | — | — |
| 3PNC | Ternary crystal structure of a polymerase lambda variant with a GT mispair at the primer terminus… | x-ray diffraction | A | — | — |
| 3PNC | Ternary crystal structure of a polymerase lambda variant with a gt mispair at the primer terminus… | x-ray diffraction | A | — | — |
| 3UPQ | Crystal structure of the pre-catalytic ternary complex of polymerase lambda with an rATP analog… | x-ray diffraction | A | — | — |
| 3UPQ | Crystal structure of the pre-catalytic ternary complex of polymerase lambda with an ratp analog… | x-ray diffraction | A | — | — |
| 3UQ0 | Crystal structure of the post-catalytic product complex of polymerase lambda with an rAMP at the… | x-ray diffraction | A | — | — |
| 3UQ0 | Crystal structure of the post-catalytic product complex of polymerase lambda with an ramp at the… | x-ray diffraction | A | — | — |
90 records more on the page itself.
Ligands
- NA · Sodium ion · in 45 records
- MG · Magnesium ion · in 30 records
- PPV · Pyrophosphate · in 22 records
- CL · Chloride ion · in 13 records
- MN · Manganese (II) ion · in 12 records
- TTP · Thymidine-5'-triphosphate · in 10 records
- DUP · 2'-deoxyuridine 5'-alpha,beta-imido-triphosphate · in 9 records
- CA · Calcium ion · in 8 records
- SO4 · Sulfate ion · in 7 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 6 records
- PO4 · Phosphate ion · in 3 records
- SRT · S,R meso-tartaric acid · in 3 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 2 records
- K · Potassium ion · in 2 records
- DCT · 2',3'-dideoxycytidine 5'-triphosphate · in 1 record
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 1 record
- OXL · Oxalate ion · in 1 record
- YQS · [[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
Experiment against prediction
- 7M43 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.48 Å
- 7M4C chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.50 Å
- 7M4C chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.50 Å
- 7M44 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.49 Å
- 7M44 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.49 Å
- 7M4B chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.50 Å
- 7M49 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.50 Å
- 7M4A chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.51 Å
- 7M46 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.50 Å
- 7M48 chain A against the predicted model Q9UGP5: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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