F2A · 2'-deoxy-5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]adenosine

Binding sites

F2A in 19 structures; the first of them:

• 3C2L · Ternary complex of DNA POLYMERASE BETA with a C:DAPCPP mismatch in the active site · F2A A338 · binds DC6, DC10, ARG149, GLY179, SER180, ARG183, SER188, GLY189 and 12 more
• 3C2M · Ternary complex of DNA POLYMERASE BETA with a G:dAPCPP mismatch in the active site · F2A A338 · binds DG6, DC10, ARG149, GLY179, SER180, ARG183, SER188, GLY189 and 11 more
• 3ISD · Ternary complex of human DNA polymerase beta with an abasic site (THF): DAPCPP mismatch · F2A A412 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 10 more
• 3RJF · Ternary complex of DNA Polymerase Beta with a gapped DNA containing (syn)8odG at template… · F2A A338 · binds GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192, ASP256 and 10 more
• 4F5P · Open ternary mismatch complex of R283K DNA polymerase beta with a dATP analog · F2A A404 · binds ARG149, GLY179, SER180, ARG183, SER187, SER188, GLY189, ASP190 and 9 more
• 4FO6 · Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP… · F2A A606 · binds ARG386, GLY416, SER417, ARG420, CYS425, GLY426, ASP427, ASP429 and 13 more
• 4GXK · R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog · F2A A404 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 11 more
• 5BPC · DNA polymerase beta ternary complex with a templating 5ClC and incoming dATP analog · F2A A405 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 11 more
• 7S9Q · Ternary complex of DNA Polymerase Beta with Template Fapy-dG and an incoming dATP analog · F2A A406 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 9 more
• 8VBG · Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM · F2A A601 · binds ILE63, LYS65, LYS70, ARG72, LEU74, ASP110, VAL111, GLY112 and 11 more
• 3C2L · Ternary complex of DNA polymerase beta with a C:DAPCPP mismatch in the active site · F2A A338 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 12 more
• 3C2M · Ternary complex of DNA polymerase beta with a G:DAPCPP mismatch in the active site · F2A A338 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 11 more
• 3ISD · Ternary complex of human DNA polymerase beta with an abasic site (thf): dapcpp mismatch · F2A A412 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 10 more
• 3RJF · Ternary complex of DNA polymerase beta with a gapped DNA containing (SYN)8ODG at template… · F2A A338 · binds GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192, ASP256 and 10 more
• 4F5P · Open ternary mismatch complex of R283K DNA polymerase beta with a datp analog · F2A A404 · binds ARG149, GLY179, SER180, ARG183, SER187, SER188, GLY189, ASP190 and 9 more
• 4FO6 · Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a datp… · F2A A606 · binds ARG386, GLY416, SER417, ARG420, CYS425, GLY426, ASP427, ASP429 and 13 more
• 4GXK · R283K DNA polymerase beta ternary complex with a templating 8OG and incoming datp analog · F2A A404 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 11 more
• 5BPC · DNA polymerase beta ternary complex with a templating 5CLC and incoming datp analog · F2A A405 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 11 more
• 7S9Q · Ternary complex of DNA polymerase beta with template fapy-dg and an incoming datp analog · F2A A406 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 9 more

Residues it binds most

ASP 19, GLY 19, SER 18, ARG 19, TYR 19, ASN 18, PHE 18, THR 18, DC 11, LYS 11 (residue and the binding sites it lines).

Found with

• NA · Sodium ion
• MN · Manganese (II) ion
• MG · Magnesium ion
• CL · Chloride ion
• EDO · 1,2-ethanediol