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Ligand · DCT

DCT · 2',3'-dideoxycytidine 5'-triphosphate

DCT, 2',3'-dideoxycytidine 5'-triphosphate (C9 H16 N3 O12 P3, 451.2 g/mol), in the MolNFT structures on GenesisL1: bound in 15 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
DCT
Formula
C9 H16 N3 O12 P3
Class
ligand
Structures
15
PDB entries
10

Binding sites

DCT in 15 structures; the first of them:

  • 5IIJ · Crystal structure of the pre-catalytic ternary complex of DNA polymerase lambda with a… · DCT A601 · binds ARG386, GLY416, SER417, ARG420, CYS425, GLY426, ASP427, ASP429 and 8 more
  • 6GO4 · TdT chimera (Loop1 of pol mu) - binary complex with ddCTP · DCT A603 · binds GLY332, GLY333, ARG336, GLY341, HIS342, ASP343, ASP345, ASP400 and 6 more
  • 6GO6 · TdT chimera (Loop1 of pol mu) - ternary complex with downstream dsDNA · DCT A603 · binds GLY332, GLY333, ARG336, LYS338, GLY341, HIS342, ASP343, ASP345 and 10 more
  • 6GO7 · TdT chimera (Loop1 of pol mu) - full DNA synapsis complex · DCT A602 · binds GLY332, GLY333, ARG336, LYS338, GLY341, HIS342, ASP343, ASP345 and 7 more
  • 6VDD · POL domain of Pol1 from M. smegmatis complex with DNA primer-template and dNTP · DCT A1001 · binds SER686, GLN687, HIS713, ARG733, LYS737, TYR741, ASP861, DA11
  • 9ICN · DNA polymerase beta (E.C.2.7.7.7)/DNA complex + 2',3'-dideoxycytidine-5'-triphosphate… · DCT A338 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190
  • 6GO4 · Tdt chimera (LOOP1 of pol mu) - binary complex with ddctp · DCT A603 · binds GLY332, GLY333, ARG336, GLY341, HIS342, ASP343, ASP345, ASP400 and 6 more
  • 6GO6 · Tdt chimera (LOOP1 of pol mu) - ternary complex with downstream dsdna · DCT A603 · binds GLY332, GLY333, ARG336, LYS338, GLY341, HIS342, ASP343, ASP345 and 10 more
  • 6GO7 · Tdt chimera (LOOP1 of pol mu) - full DNA synapsis complex · DCT A602 · binds GLY332, GLY333, ARG336, LYS338, GLY341, HIS342, ASP343, ASP345 and 7 more
  • 6KWR · Crystal structure of enterovirus 71 polymerase elongation complex (ddctp form) · DCT A503 · binds ARG174, TYR234, GLY236, ASP238, ASP329, G600, G601, DOC701
  • 6P2G · Structure of HIV-1 reverse transcriptase (rt) in complex with dsdna and D-ddctp · DCT A601 · binds ARG72, ASP110, VAL111, GLY112, ASP113, ALA114, TYR115, GLN151 and 5 more
  • 6VDD · Pol domain of POL1 from M. smegmatis complex with DNA primer-template and dntp · DCT A1001 · binds GLN687, HIS713, ARG733, LYS737, TYR741, DA11
  • 7RR3 · Structure of deep-sea phage nrs-1 primase-polymerase N300 in complex with calcium and… · DCT A304 · binds LYS27, PHE76, ASP78, ASP80, SER108, PRO109, SER110, HIS115 and 3 more
  • 9ICN · DNA polymerase beta (E.C.2.7.7.7)/DNA complex + 2',3'- dideoxycytidine-5'-triphosphate… · DCT A338 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190
  • 9ICS · DNA polymerase beta (E.C.2.7.7.7)/DNA complex + 2',3'- dideoxycytidine-5'-triphosphate… · DCT A338 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 3 more

Residues it binds most

GLY 12, ARG 17, ASP 14, HIS 11, SER 6, LYS 9, TYR 9, TRP 6, ASN 5, DG 5 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • NA · Sodium ion
  • CA · Calcium ion
  • MN · Manganese (II) ion
  • ZN · Zinc ion
  • SO4 · Sulfate ion

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