UniProt Q8NET8
Transient receptor potential cation channel subfamily V member 3 (Q8NET8)
Transient receptor potential cation channel subfamily V member 3 (UniProt Q8NET8): 26 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 111 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8NET8
- Protein
- Transient receptor potential cation channel subfamily V member 3
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 111 · 6 records with a druggable one
Structures
27 records of Q8NET8 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6H9J | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) | x-ray diffraction | D | — | — |
| 6H9J | Factor inhibiting hif (fih) in complex with zinc, nog and TRPV3 (229- 255) | x-ray diffraction | D | — | — |
| 6HA6 | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246) | x-ray diffraction | D | — | — |
| 6HA6 | Factor inhibiting hif (fih) in complex with zinc, nog and TRPV3 (220- 246) | x-ray diffraction | D | — | — |
| 6MHO | Structure of the human TRPV3 channel in the apo conformation | electron microscopy | B, C, A, D | — | — |
| 6MHS | Structure of the human TRPV3 channel in a putative sensitized conformation | electron microscopy | B, C, A, D | — | — |
| 6MHV | Structure of human TRPV3 in the presence of 2-APB in C4 symmetry | electron microscopy | B, C, A, D | — | — |
| 6MHV | Structure of human TRPV3 in the presence of 2-apb in C4 symmetry | electron microscopy | B, C, A, D | — | — |
| 6MHW | Structure of human TRPV3 in the presence of 2-apb in C2 symmetry (1) | electron microscopy | A, B, C, D | — | — |
| 6MHX | Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (2) | electron microscopy | B, A, C, D | — | — |
| 6MHX | Structure of human TRPV3 in the presence of 2-apb in C2 symmetry (2) | electron microscopy | B, A, C, D | — | — |
| 6OT2 | Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | electron microscopy | A, B, D, C | — | 20 (best 0.82) |
| 6OT2 | Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 a resolution | electron microscopy | A, B, D, C | — | — |
| 6OT5 | Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | electron microscopy | A, B, C, D | FZ4 | 20 (best 0.87) |
| 6OT5 | Structure of the TRPV3 K169A sensitized mutant in the presence of 2- apb at 3.6 a resolution | electron microscopy | A, B, C, D | FZ4 | — |
| 6UW4 | Cryo-EM structure of human TRPV3 determined in lipid nanodisc | electron microscopy | A, B, C, D | 6OU, NA | — |
| 6UW4 | Cryo-EM structure of human TRPV3 determined in lipid nanodisc | electron microscopy | A, B, C, D | 6OU, NA | — |
| 6UW6 | Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc | electron microscopy | A, B, C, D | 6OU | — |
| 6UW8 | Cryo-EM structure of the human TRPV3 K169A mutant briefly exposed to 2-apb for 3 minutes… | electron microscopy | A, B, C, D | — | — |
| 6UW9 | Cryo-EM structure of the human TRPV3 K169A mutant in the presence of 2-APB, determined in lipid… | electron microscopy | A, B, C, D | — | — |
| 6UW9 | Cryo-EM structure of the human TRPV3 K169A mutant in the presence of 2-apb, determined in lipid… | electron microscopy | A, B, C, D | — | — |
| 7QQN | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 | x-ray diffraction | B, D | — | — |
| 7QQN | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 | x-ray diffraction | B, D | — | — |
| 8V6M | Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in… | electron microscopy | A, B, C, D | POV, I8E, NA | 20 (best 0.86) |
| 8V6N | Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs | electron microscopy | A, B, C, D | POV, ACD, FZ4 | 20 (best 0.82) |
| 8V6O | Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs | electron microscopy | A, B, C, D | POV, FZ4, NA | 20 (best 0.82) |
| Q8NET8 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V… | predicted | A | — | 11 (best 0.67) |
Ligands
- FZ4 · 2-aminoethyl diphenylborinate · in 4 records
- NA · Sodium ion · in 4 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- ACD · Arachidonic acid · in 1 record
- I8E · Tetrahydrocannabivarin · in 1 record
Experiment against prediction
- 6MHX chain B against the predicted model Q8NET8: TM-score 0.98, RMSD 1.24 Å
- 6MHX chain B against the predicted model Q8NET8: TM-score 0.98, RMSD 1.24 Å
- 6MHW chain A against the predicted model Q8NET8: TM-score 0.98, RMSD 1.24 Å
- 6MHS chain B against the predicted model Q8NET8: TM-score 0.98, RMSD 1.29 Å
- 6UW4 chain A against the predicted model Q8NET8: TM-score 0.98, RMSD 1.40 Å
- 6UW4 chain A against the predicted model Q8NET8: TM-score 0.98, RMSD 1.40 Å
- 6MHV chain B against the predicted model Q8NET8: TM-score 0.97, RMSD 1.34 Å
- 6MHV chain B against the predicted model Q8NET8: TM-score 0.97, RMSD 1.34 Å
- 6MHO chain B against the predicted model Q8NET8: TM-score 0.97, RMSD 1.32 Å
- 8V6M chain A against the predicted model Q8NET8: TM-score 0.96, RMSD 1.70 Å
Elsewhere
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