MolNFT v1 · #166631 · protein
Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc
6UW6 · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc”. Electron microscopy, 1 ligand (6OU), 20 pockets (best druggability 0.83). MolNFT v1 #166631…
- PDB
- 6UW6
- Type
- protein
- Length
- 2,408 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8NET8
- Ligands
- 6OU
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 57% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 3 | protein | 602 | 57% helix, 3% strand | Q8NET8 |
Ligands and binding sites
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 20 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.83 | 0.84 | 62 | empty |
| 2 | 455 | 0.70 | 0.80 | 41 | 6OU |
| 3 | 413 | 0.70 | 0.81 | 36 | 6OU |
| 4 | 439 | 0.70 | 0.80 | 43 | 6OU |
| 5 | 443 | 0.68 | 0.80 | 44 | 6OU |
Interfaces
4 interfaces between chains.
- A–D · 2600 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 2560 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 2559 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 2556 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6UW6 · Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6UW6 · PDBe 6UW6 · UniProt Q8NET8
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