MolNFT v1 · #156873 · protein
Structure of the human TRPV3 channel in a putative sensitized conformation
6MHS · Transient receptor potential cation channel subfamily V…: “Structure of the human TRPV3 channel in a putative sensitized conformation”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #156873 on GenesisL1: 3D…
- PDB
- 6MHS
- Type
- protein
- Length
- 2,428 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8NET8
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C, A, D | Transient receptor potential cation channel subfamily V member 3 | protein | 607 | 60% helix, 5% strand | Q8NET8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.86 | 0.87 | 85 | empty |
| 2 | 1034 | 0.78 | 0.79 | 79 | empty |
| 3 | 1112 | 0.78 | 0.79 | 86 | empty |
| 4 | 1107 | 0.77 | 0.79 | 88 | empty |
| 5 | 1088 | 0.77 | 0.79 | 84 | empty |
Interfaces
4 interfaces between chains.
- B–A · 2545 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 2543 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 2540 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 2530 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6MHS · Structure of the human TRPV3 channel in a putative sensitized conformation · the same entry in another collection · chain B against B, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6MHS · PDBe 6MHS · UniProt Q8NET8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.