MolNFT v1 · #159546 · protein
Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 a resolution
6OT2 · Transient receptor potential cation channel subfamily V…: “Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 a resolution”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #159546 on GenesisL1: 3D…
- PDB
- 6OT2
- Type
- protein
- Length
- 2,500 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8NET8
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, C | Transient receptor potential cation channel subfamily V member 3 | protein | 625 | 61% helix, 4% strand | Q8NET8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.82 | 0.83 | 81 | empty |
| 2 | 672 | 0.78 | 0.83 | 81 | empty |
| 3 | 534 | 0.78 | 0.84 | 73 | empty |
| 4 | 429 | 0.75 | 0.84 | 59 | empty |
| 5 | 617 | 0.72 | 0.79 | 55 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2613 Ų buried · 11 hydrogen bonds · protein-protein
- D–C · 2611 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 2606 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 2605 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6OT2 · Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6OT2 · PDBe 6OT2 · UniProt Q8NET8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.