MolNFT v1 · #156869 · protein
Structure of the human TRPV3 channel in the apo conformation
6MHO · Transient receptor potential cation channel subfamily V…: “Structure of the human TRPV3 channel in the apo conformation”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #156869 on GenesisL1: 3D structure…
- PDB
- 6MHO
- Type
- protein
- Length
- 2,404 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8NET8
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C, A, D | Transient receptor potential cation channel subfamily V member 3 | protein | 601 | 60% helix, 4% strand | Q8NET8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1186 | 0.84 | 0.84 | 100 | empty |
| 2 | 575 | 0.72 | 0.79 | 42 | empty |
| 3 | 909 | 0.71 | 0.76 | 120 | empty |
| 4 | 575 | 0.71 | 0.79 | 45 | empty |
| 5 | 551 | 0.70 | 0.79 | 48 | empty |
Interfaces
6 interfaces between chains.
- B–A · 2382 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 2342 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 2333 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 2320 Ų buried · 10 hydrogen bonds · protein-protein
- C–A · 13 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6MHO · Structure of the human TRPV3 channel in the apo conformation · the same entry in another collection · chain B against B, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6MHO · PDBe 6MHO · UniProt Q8NET8
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