MolNFT v1 · #159548 · protein
Structure of the TRPV3 K169A sensitized mutant in the presence of 2- apb at 3.6 a resolution
6OT5 · Transient receptor potential cation channel subfamily V…: “Structure of the TRPV3 K169A sensitized mutant in the presence of 2- apb at 3.6 a resolution”. Electron microscopy, 1 ligand (FZ4), 20 pockets (best druggability 0.87).…
- PDB
- 6OT5
- Type
- protein
- Length
- 2,492 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3,TRANSIENT receptor…
- UniProt
- Q8NET8
- Ligands
- FZ4
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 3,TRANSIENT receptor potential cation channel subfamily V member 3 | protein | 623 | 60% helix, 4% strand | Q8NET8 |
Ligands and binding sites
- FZ4 · 2-aminoethyl diphenylborinate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1160 | 0.87 | 0.87 | 119 | empty |
| 2 | 420 | 0.70 | 0.81 | 29 | empty |
| 3 | 433 | 0.70 | 0.81 | 29 | empty |
| 4 | 439 | 0.70 | 0.81 | 28 | empty |
| 5 | 436 | 0.70 | 0.80 | 31 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2697 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 2696 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 2695 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 2687 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 covalent, 4 disulfide (covalent ligand, disulfide).
Compared structures
- 6OT5 · Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6OT5 · PDBe 6OT5 · UniProt Q8NET8
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