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Ligand · ACD

ACD · Arachidonic acid

ACD, Arachidonic acid (C20 H32 O2, 304.5 g/mol), in the MolNFT structures on GenesisL1: bound in 19 records (14 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
ACD
Formula
C20 H32 O2
Class
ligand
Structures
19
PDB entries
14

Binding sites

ACD in 19 structures; the first of them:

  • 5CSD · Ligand binding domain 2 of Penicillium marneffei MP1 protein in complex with arachidonic… · ACD A201 · binds ILE18, VAL22, PHE25, LEU40, LEU41, GLY44, LEU47, THR51 and 15 more
  • 5ECF · Ligand binding domain 1 of Penicillium marneffei MP1 protein complexed with arachidonic… · ACD B201 · binds PHE36, LEU40, ILE43, LEU89, ALA94, LEU97, VAL101, ASN105 and 6 more
  • 5FB7 · Ligand binding domain 2 of Penicillium marneffei MP1 protein complexed with multiple… · ACD A201 · binds ILE18, PHE25, LEU40, LEU41, GLY44, LEU47, THR51, ILE83 and 10 more
  • 5J5L · Crystal structure of AFMP4P in complex with arachidonic acid · ACD A201 · binds LEU44, HIS47, PHE48, PHE51, GLN57, ALA58, ALA61, GLN62 and 12 more
  • 6LX9 · X-ray structure of human PPARalpha ligand binding domain-arachidonic acid co-crystals… · ACD A502 · binds ILE241, LEU247, ALA250, GLU251, LEU254, VAL255, ILE272, PHE273 and 17 more
  • 6MCZ · Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Arachidonic… · ACD A501 · binds LEU228, GLY284, CYS285, ARG288, SER289, HIS323, TYR327, LEU330 and 9 more
  • 6MD2 · Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and… · ACD A502 · binds ILE281, GLY284, CYS285, PHE287, ARG288, GLU291, LEU330, VAL339 and 6 more
  • 6NBN · Structure of Aedes aegypti OBP22 in the complex with arachidonic acid · ACD A201 · binds LEU11, ARG15, PHE32, TRP35, PHE37, TYR46, ILE47, VAL50 and 16 more
  • 6OII · Structure of Aedes aegypti OBP22 in the complex with arachidonic acid · ACD A202 · binds LEU11, ARG15, PHE32, TRP35, PHE37, TYR46, ILE47, VAL50 and 16 more
  • 7WJ1 · The 0.86 angstrom X-ray structure of the human heart fatty acid-binding protein complexed… · ACD A200 · binds PHE16, TYR19, MET20, LEU23, VAL25, THR29, ALA33, THR36 and 16 more
  • 8GHD · The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid · ACD A903 · binds PHE174, LEU178, PHE352, GLU356, HIS360, LEU361, HIS365, ILE399 and 12 more
  • 8V6N · Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs · ACD A902 · binds TRP521, PHE522, VAL525, ILE528, LEU557, ALA560, LEU563, SER576 and 4 more
  • 8XGF · Human Cx36/GJD2 gap junction channel in complex with arachidonic acid. · ACD A406 · binds ILE35, ALA39, ILE40, ILE83, ILE84, CYS87, LEU91, ILE40

Residues it binds most

ILE 59, LEU 58, VAL 36, PHE 44, SER 48, ALA 44, GLN 26, CYS 28, HIS 13, ARG 21 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • GW9 · 2-chloro-5-nitro-N-phenylbenzamide
  • CD · Cadmium ion
  • CO · Cobalt (II) ion
  • EDO · 1,2-ethanediol
  • AKR · Acrylic acid
  • COH · Protoporphyrin IX containing co
  • FZ4 · 2-aminoethyl diphenylborinate
  • MC3 · 1,2-dimyristoyl-rac-glycero-3-phosphocholine
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • ZR5 · N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide
  • FE2 · Fe (II) ion

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