UniProt Q07343
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Q07343)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (UniProt Q07343), EC 3.1.4.53: 78 experimental structures on GenesisL1, 8 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q07343
- Protein
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D
- EC
- 3.1.4.53
- Experimental structures
- 78
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 19 · 3 records with a druggable one
Structures
78 records of Q07343 in the MolNFT archive: 78 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F0J | Catalytic domain of human phosphodiesterase 4B2B | x-ray diffraction | A, B | — | — |
| 1F0J | Catalytic domain of human phosphodiesterase 4B2B | x-ray diffraction | A, B | — | — |
| 1RO6 | Crystal structure of PDE4B2B complexed with Rolipram (R & S) | x-ray diffraction | A, B | — | — |
| 1RO6 | Crystal structure of PDE4B2B complexed with rolipram (R & S) | x-ray diffraction | A, B | — | — |
| 1RO9 | CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP | x-ray diffraction | A, B | — | — |
| 1RO9 | Crystal structures of the catalytic domain of phosphodiesterase 4B2B complexed with 8-br-AMP | x-ray diffraction | A, B | — | — |
| 1ROR | Crystal structures of the catalytic domain of phosphodiesterase 4B2B complexed with AMP | x-ray diffraction | A, B | — | — |
| 1ROR | Crystal structures of the catalytic domain of phosphodiesterase 4B2B complexed with AMP | x-ray diffraction | A, B | — | — |
| 1TB5 | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP | x-ray diffraction | A, B | — | — |
| 1TB5 | Catalytic domain of human phosphodiesterase 4B in complex with AMP | x-ray diffraction | A, B | — | — |
| 1XLX | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast | x-ray diffraction | A, B | — | — |
| 1XLX | Catalytic domain of human phosphodiesterase 4B in complex with cilomilast | x-ray diffraction | A, B | — | — |
| 1XLZ | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast | x-ray diffraction | A, B | — | — |
| 1XLZ | Catalytic domain of human phosphodiesterase 4B in complex with filaminast | x-ray diffraction | A, B | — | — |
| 1XM4 | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast | x-ray diffraction | A, B | — | — |
| 1XM4 | Catalytic domain of human phosphodiesterase 4B in complex with piclamilast | x-ray diffraction | A, B | — | — |
| 1XM6 | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram | x-ray diffraction | A, B | — | — |
| 1XM6 | Catalytic domain of human phosphodiesterase 4B in complex with (R)- mesopram | x-ray diffraction | A, B | — | — |
| 1XMU | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast | x-ray diffraction | A, B | — | — |
| 1XMU | Catalytic domain of human phosphodiesterase 4B in complex with roflumilast | x-ray diffraction | A, B | — | — |
| 1XMY | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram | x-ray diffraction | A, B | — | — |
| 1XMY | Catalytic domain of human phosphodiesterase 4B in complex with (R)- rolipram | x-ray diffraction | A, B | — | — |
| 1XN0 | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram | x-ray diffraction | A, B | — | — |
| 1XN0 | Catalytic domain of human phosphodiesterase 4B in complex with (R,S)- rolipram | x-ray diffraction | A, B | — | — |
| 1XOS | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil | x-ray diffraction | A | — | — |
| 1XOS | Catalytic domain of human phosphodiesterase 4B in complex with sildenafil | x-ray diffraction | A | — | — |
| 1XOT | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil | x-ray diffraction | B, A | — | — |
| 1XOT | Catalytic domain of human phosphodiesterase 4B in complex with vardenafil | x-ray diffraction | B, A | — | — |
| 1Y2H | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With… | x-ray diffraction | A, B | — | — |
| 1Y2H | Catalytic domain of human phosphodiesterase 4B in complex with 1-(2… | x-ray diffraction | A, B | — | — |
| 1Y2J | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With… | x-ray diffraction | A, B | — | — |
| 1Y2J | Catalytic domain of human phosphodiesterase 4B in complex with 3,5… | x-ray diffraction | A, B | — | — |
| 2CHM | Crystal structure of N2 substituted pyrazolo pyrimidi s - a flipped binding mode in PDE5 | x-ray diffraction | A | — | — |
| 2CHM | Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5 | x-ray diffraction | A | — | — |
| 3D3P | Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor | x-ray diffraction | A | — | — |
| 3D3P | Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor | x-ray diffraction | A | — | — |
| 3FRG | Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor | x-ray diffraction | A | — | — |
| 3FRG | Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor | x-ray diffraction | A | — | — |
| 3G45 | Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 | x-ray diffraction | A, B | — | — |
| 3G45 | Crystal structure of human phosphodiesterase 4B with regulatory domain and D155988 | x-ray diffraction | A, B | — | — |
| 3GWT | Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor | x-ray diffraction | A | — | — |
| 3GWT | Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor | x-ray diffraction | A | — | — |
| 3HMV | Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene… | x-ray diffraction | A, B | — | — |
| 3HMV | Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene… | x-ray diffraction | A, B | — | — |
| 3KKT | Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp… | x-ray diffraction | A, B | — | — |
| 3KKT | Crystal structure of human PDE4B with 5-[3-[(1S,2S,4R)- BICYCLO[2.2.1]HEPT-2-yloxy]-4-methoxyp… | x-ray diffraction | A, B | — | — |
| 3LY2 | Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3LY2 | Catalytic domain of human phosphodiesterase 4B in complex with a coumarin-based inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3O0J | PDE4B In complex with ligand an2898 | x-ray diffraction | A | — | — |
| 3O0J | PDE4B in complex with ligand AN2898 | x-ray diffraction | A | — | — |
| 3O56 | Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine… | x-ray diffraction | A | — | — |
| 3O56 | Catalytic domain of human phosphodiesterase 4B2B in complex with a 5- heterocycle pyrazolopyridine… | x-ray diffraction | A | — | — |
| 3O57 | Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine… | x-ray diffraction | A | — | — |
| 3O57 | Catalytic domain of human phosphodiesterase 4B2B in complex with a 5- heterocycle pyrazolopyridine… | x-ray diffraction | A | — | — |
| 3W5E | Crystal structure of phosphodiesterase 4B in complex with compound 31e | x-ray diffraction | A, B | — | — |
| 3W5E | Crystal structure of phosphodiesterase 4B in complex with compound 31E | x-ray diffraction | A, B | — | — |
| 3WD9 | Crystal structure of phosphodiesterase 4B in complex with compound 10f | x-ray diffraction | A, B | — | — |
| 3WD9 | Crystal structure of phosphodiesterase 4B in complex with compound 10F | x-ray diffraction | A, B | — | — |
| 4KP6 | Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative | x-ray diffraction | A | — | — |
| 4KP6 | Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]TRIAZINE derivative | x-ray diffraction | A | — | — |
18 records more on the page itself.
Ligands
- MG · Magnesium ion · in 9 records
- ZN · Zinc ion · in 9 records
- 6M5 · (4~{A}~{S},8~{A}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl) phenoxy]butoxy]phenyl]-4~{A},5,8,8~{A}-tetrahydrophthalazin-1-one · in 2 records
- 6QQ · 6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile · in 2 records
- 9VE · [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-1-ium-4-yl]-1-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]ethyl] (2~{S})-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate · in 2 records
- CL · Chloride ion · in 2 records
- E31 · 2-(4-{[2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl]methyl}phenyl)acetamide · in 2 records
- VL9 · [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-4-yl]-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[(1~{R})-2-[[(3~{R})-1-azabicyclo[2.2.2]octan-3-yl]oxy]-2-oxidanylidene-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate · in 1 record
Elsewhere
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